| Title |
Secondary infection as a risk factor for dengue hemorrhagic fever/dengue shock syndrome: an historical perspective and role of antibody-dependent enhancement of infection
|
|---|---|
| Published in |
Archives of Virology, March 2013
|
| DOI | 10.1007/s00705-013-1645-3 |
| Pubmed ID | |
| Authors |
Maria G. Guzman, Mayling Alvarez, Scott B. Halstead |
| Abstract |
Today, dengue viruses are the most prevalent arthropod-borne viruses in the world. Since the 1960s, numerous reports have identified a second heterologous dengue virus (DENV) infection as a principal risk factor for severe dengue disease (dengue hemorrhagic fever/dengue shock syndrome, DHF/DSS). Modifiers of dengue disease response include the specific sequence of two DENV infections, the interval between infections, and contributions from the human host, such as age, ethnicity, chronic illnesses and genetic background. Antibody-dependent enhancement (ADE) of dengue virus infection has been proposed as the early mechanism underlying DHF/DSS. Dengue cross-reactive antibodies raised following a first dengue infection combine with a second infecting virus to form infectious immune complexes that enter Fc-receptor-bearing cells. This results in an increased number of infected cells and increased viral output per cell. At the late illness stage, high levels of cytokines, possibly the result of T cell elimination of infected cells, result in vascular permeability, leading to shock and death. This review is focused on the etiological role of secondary infections (SI) and mechanisms of ADE. |
X Demographics
The data shown below were collected from the profiles of 23 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 2 | 9% |
| United States | 2 | 9% |
| Comoros | 2 | 9% |
| Portugal | 1 | 4% |
| Unknown | 16 | 70% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 20 | 87% |
| Scientists | 2 | 9% |
| Science communicators (journalists, bloggers, editors) | 1 | 4% |
Mendeley readers
The data shown below were compiled from readership statistics for 608 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Mexico | 2 | <1% |
| United States | 2 | <1% |
| Vietnam | 2 | <1% |
| France | 1 | <1% |
| Sweden | 1 | <1% |
| Germany | 1 | <1% |
| Singapore | 1 | <1% |
| Malaysia | 1 | <1% |
| Japan | 1 | <1% |
| Other | 1 | <1% |
| Unknown | 595 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 96 | 16% |
| Student > Ph. D. Student | 95 | 16% |
| Student > Master | 77 | 13% |
| Researcher | 74 | 12% |
| Student > Postgraduate | 33 | 5% |
| Other | 90 | 15% |
| Unknown | 143 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 106 | 17% |
| Medicine and Dentistry | 97 | 16% |
| Biochemistry, Genetics and Molecular Biology | 81 | 13% |
| Immunology and Microbiology | 67 | 11% |
| Chemistry | 16 | 3% |
| Other | 75 | 12% |
| Unknown | 166 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 50. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 August 2022.
All research outputs
#817,057
of 25,013,816 outputs
Outputs from Archives of Virology
#24
of 4,448 outputs
Outputs of similar age
#5,514
of 200,592 outputs
Outputs of similar age from Archives of Virology
#1
of 25 outputs
Altmetric has tracked 25,013,816 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,448 research outputs from this source. They receive a mean Attention Score of 3.9. This one has done particularly well, scoring higher than 99% of its peers.
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We're also able to compare this research output to 25 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.