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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Cold Exposure Promotes Atherosclerotic Plaque Growth and Instability via UCP1-Dependent Lipolysis
|
|---|---|
| Published in |
Cell Metabolism (Science Direct), July 2013
|
| DOI | 10.1016/j.cmet.2013.06.003 |
| Pubmed ID | |
| Authors |
Mei Dong, Xiaoyan Yang, Sharon Lim, Ziquan Cao, Jennifer Honek, Huixia Lu, Cheng Zhang, Takahiro Seki, Kayoko Hosaka, Eric Wahlberg, Jianmin Yang, Lei Zhang, Toste Länne, Baocun Sun, Xuri Li, Yizhi Liu, Yun Zhang, Yihai Cao |
| Abstract |
Molecular mechanisms underlying the cold-associated high cardiovascular risk remain unknown. Here, we show that the cold-triggered food-intake-independent lipolysis significantly increased plasma levels of small low-density lipoprotein (LDL) remnants, leading to accelerated development of atherosclerotic lesions in mice. In two genetic mouse knockout models (apolipoprotein E(-/-) [ApoE(-/-)] and LDL receptor(-/-) [Ldlr(-/-)] mice), persistent cold exposure stimulated atherosclerotic plaque growth by increasing lipid deposition. Furthermore, marked increase of inflammatory cells and plaque-associated microvessels were detected in the cold-acclimated ApoE(-/-) and Ldlr(-/-) mice, leading to plaque instability. Deletion of uncoupling protein 1 (UCP1), a key mitochondrial protein involved in thermogenesis in brown adipose tissue (BAT), in the ApoE(-/-) strain completely protected mice from the cold-induced atherosclerotic lesions. Cold acclimation markedly reduced plasma levels of adiponectin, and systemic delivery of adiponectin protected ApoE(-/-) mice from plaque development. These findings provide mechanistic insights on low-temperature-associated cardiovascular risks. |
X Demographics
The data shown below were collected from the profiles of 26 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 6 | 23% |
| Germany | 2 | 8% |
| Spain | 1 | 4% |
| Comoros | 1 | 4% |
| Canada | 1 | 4% |
| United Kingdom | 1 | 4% |
| Unknown | 14 | 54% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 19 | 73% |
| Practitioners (doctors, other healthcare professionals) | 3 | 12% |
| Scientists | 3 | 12% |
| Science communicators (journalists, bloggers, editors) | 1 | 4% |
Mendeley readers
The data shown below were compiled from readership statistics for 187 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 2% |
| Netherlands | 2 | 1% |
| Sweden | 1 | <1% |
| South Africa | 1 | <1% |
| Chile | 1 | <1% |
| Singapore | 1 | <1% |
| United Kingdom | 1 | <1% |
| China | 1 | <1% |
| Belgium | 1 | <1% |
| Other | 0 | 0% |
| Unknown | 174 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 38 | 20% |
| Researcher | 36 | 19% |
| Student > Master | 19 | 10% |
| Student > Bachelor | 17 | 9% |
| Student > Doctoral Student | 11 | 6% |
| Other | 31 | 17% |
| Unknown | 35 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 50 | 27% |
| Medicine and Dentistry | 39 | 21% |
| Biochemistry, Genetics and Molecular Biology | 32 | 17% |
| Immunology and Microbiology | 6 | 3% |
| Computer Science | 2 | 1% |
| Other | 11 | 6% |
| Unknown | 47 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 101. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 April 2023.
All research outputs
#427,159
of 25,753,031 outputs
Outputs from Cell Metabolism (Science Direct)
#461
of 3,204 outputs
Outputs of similar age
#2,950
of 207,590 outputs
Outputs of similar age from Cell Metabolism (Science Direct)
#2
of 47 outputs
Altmetric has tracked 25,753,031 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,204 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 74.3. This one has done well, scoring higher than 85% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 207,590 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 47 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.