| Title |
Functional Implications of an Early Exposure to General Anesthesia: Are We Changing the Behavior of Our Children?
|
|---|---|
| Published in |
Molecular Neurobiology, July 2013
|
| DOI | 10.1007/s12035-013-8488-5 |
| Pubmed ID | |
| Authors |
Vesna Jevtovic-Todorovic |
| Abstract |
There is a rapidly growing body of animal and clinical evidence suggesting that the exposure to anesthetics and sedatives during the critical stages of brain development results in long-lasting (perhaps permanent) impairment in cognitive development in a variety of mammalian species. With improved understanding of the mechanisms responsible for behavioral outcomes of anesthesia-induced developmental neurotoxicity, there is hope for development of protective strategies that will enable safe use of anesthesia in the youngest members of our society. Here, I review presently available evidence regarding anesthesia-induced neurocognitive and social behavioral impairments and possible strategies for preventing them. I also review limited and somewhat controversial evidence that examines the effects of nociception and surgical stimulation on anesthesia--induced developmental neurotoxicity. |
Mendeley readers
The data shown below were compiled from readership statistics for 45 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 2% |
| Unknown | 44 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 9 | 20% |
| Student > Master | 8 | 18% |
| Student > Doctoral Student | 5 | 11% |
| Researcher | 5 | 11% |
| Student > Ph. D. Student | 5 | 11% |
| Other | 8 | 18% |
| Unknown | 5 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 16 | 36% |
| Psychology | 8 | 18% |
| Agricultural and Biological Sciences | 6 | 13% |
| Neuroscience | 4 | 9% |
| Business, Management and Accounting | 2 | 4% |
| Other | 2 | 4% |
| Unknown | 7 | 16% |