Title |
Can Vaccinations Improve Heart Failure Outcomes? Contemporary Data and Future Directions
|
---|---|
Published in |
JACC: Heart Failure, February 2017
|
DOI | 10.1016/j.jchf.2016.12.007 |
Pubmed ID | |
Authors |
Ankeet S. Bhatt, Adam D. DeVore, Adrian F. Hernandez, Robert J. Mentz |
Abstract |
Heart failure (HF) is a chronic syndrome characterized by acute exacerbations. There is significant overlap between respiratory infections and exacerbation of underlying HF. Vaccination against respiratory infections in patients with HF could serve as a potential cost-effective intervention to improve patients' quality of life and clinical outcomes. The benefits of influenza vaccination in secondary prevention of ischemic heart disease have been previously studied. However, the evidence for influenza and pneumococcal vaccination specifically in the HF population is less well established. Furthermore, questions around the optimal timing, dose, frequency, and implementation strategies are largely unanswered. This review highlights the current evidence for vaccination against influenza and pneumococcal pneumonia in HF and cardiovascular disease. It summarizes current understanding of the pathophysiologic mechanisms in which vaccination may provide cardioprotection. Finally, it offers opportunities for further investigation of the effects of vaccination in the HF population, spanning basic science, translational research, and large clinical trials. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 35 | 24% |
Spain | 18 | 12% |
United Kingdom | 6 | 4% |
Chile | 3 | 2% |
Brazil | 3 | 2% |
Argentina | 2 | 1% |
Guinea | 2 | 1% |
Paraguay | 2 | 1% |
Venezuela, Bolivarian Republic of | 2 | 1% |
Other | 18 | 12% |
Unknown | 55 | 38% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 97 | 66% |
Practitioners (doctors, other healthcare professionals) | 24 | 16% |
Scientists | 21 | 14% |
Science communicators (journalists, bloggers, editors) | 4 | 3% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 87 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 12 | 14% |
Student > Master | 11 | 13% |
Researcher | 10 | 11% |
Student > Ph. D. Student | 8 | 9% |
Other | 6 | 7% |
Other | 15 | 17% |
Unknown | 25 | 29% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 31 | 36% |
Nursing and Health Professions | 8 | 9% |
Immunology and Microbiology | 2 | 2% |
Psychology | 2 | 2% |
Neuroscience | 2 | 2% |
Other | 11 | 13% |
Unknown | 31 | 36% |