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Rectal microbiota among HIV-uninfected, untreated HIV, and treated HIV-infected in Nigeria

Overview of attention for article published in AIDS, March 2017
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6 X users
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99 Mendeley
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Title
Rectal microbiota among HIV-uninfected, untreated HIV, and treated HIV-infected in Nigeria
Published in
AIDS, March 2017
DOI 10.1097/qad.0000000000001409
Pubmed ID
Authors

Rebecca G. Nowak, Søren M. Bentzen, Jacques Ravel, Trevor A. Crowell, Wuese Dauda, Bing Ma, Hongjie Liu, William A. Blattner, Stefan D. Baral, Manhattan E. Charurat

Abstract

Untreated advanced HIV infection alters the gut microbiota, but it is unclear whether antiretroviral therapy (ART) reverses these changes. We compared the composition of the rectal microbiota among three groups of men who have sex with men (MSM): HIV-uninfected, untreated HIV, and ART-treated HIV-infected. A cross-sectional study was conducted among 130 MSM (55 HIV-uninfected, 41 untreated HIV, 34 ART-treated HIV) in Abuja, Nigeria. Bacterial 16S rRNA genes were amplified from rectal swabs, sequenced and clustered into Genera-level operational taxonomic units. Alpha diversity was quantified using the Shannon Index and compared among groups using the Kruskal-Wallis test; Associations with other scale variables were quantified using Spearman's Rank Correlation (Rs). The relative abundance of the top 15 taxa was compared according to HIV infection/treatment status using the Wilcoxon-Rank sum test. HIV treated MSM had a decrease in a commensal phylum, Bacteroidetes (p < 0.01). Alpha diversity was positively correlated with viral loads (Rs = 0.32, p < 0.01). Statistically significant shifts in relative abundance of rectal microbiota for the HIV treated group included a decrease in the most abundant bacteria, Prevotella (p = 0.02) and an increase in pathogenic bacteria, Peptoniphilus (p = 0.04), Finegoldia (p = 0.01), Anaerococcus (p = 0.03), and Campylobacter (p = 0.03) as compared to the other groups. Untreated HIV infection does not significantly alter the rectal microbiota, whereas prior treatment is associated with a shift towards a more pathogenic pattern of microbiota. Treatment with an antibiotic, co-trimoxazole, in conjunction with ART may have contributed to this shift.

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X Demographics

The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 99 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 99 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 18 18%
Researcher 13 13%
Student > Ph. D. Student 13 13%
Student > Bachelor 10 10%
Student > Doctoral Student 8 8%
Other 13 13%
Unknown 24 24%
Readers by discipline Count As %
Medicine and Dentistry 25 25%
Immunology and Microbiology 20 20%
Agricultural and Biological Sciences 15 15%
Biochemistry, Genetics and Molecular Biology 5 5%
Nursing and Health Professions 3 3%
Other 5 5%
Unknown 26 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 January 2018.
All research outputs
#14,602,949
of 25,377,790 outputs
Outputs from AIDS
#4,470
of 6,481 outputs
Outputs of similar age
#160,518
of 323,059 outputs
Outputs of similar age from AIDS
#49
of 81 outputs
Altmetric has tracked 25,377,790 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 6,481 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.9. This one is in the 30th percentile – i.e., 30% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 323,059 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 49th percentile – i.e., 49% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 81 others from the same source and published within six weeks on either side of this one. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.