| Title |
Transport Effects on Multiple-Component Reactions in Optical Biosensors
|
|---|---|
| Published in |
Bulletin of Mathematical Biology, August 2017
|
| DOI | 10.1007/s11538-017-0327-9 |
| Pubmed ID | |
| Authors |
Ryan M. Evans, David A. Edwards |
| Abstract |
Optical biosensors are often used to measure kinetic rate constants associated with chemical reactions. Such instruments operate in the surface-volume configuration, in which ligand molecules are convected through a fluid-filled volume over a surface to which receptors are confined. Currently, scientists are using optical biosensors to measure the kinetic rate constants associated with DNA translesion synthesis-a process critical to DNA damage repair. Biosensor experiments to study this process involve multiple interacting components on the sensor surface. This multiple-component biosensor experiment is modeled with a set of nonlinear integrodifferential equations (IDEs). It is shown that in physically relevant asymptotic limits these equations reduce to a much simpler set of ordinary differential equations (ODEs). To verify the validity of our ODE approximation, a numerical method for the IDE system is developed and studied. Results from the ODE model agree with simulations of the IDE model, rendering our ODE model useful for parameter estimation. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Norway | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 5 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 5 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 3 | 60% |
| Student > Bachelor | 1 | 20% |
| Unknown | 1 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Engineering | 2 | 40% |
| Chemistry | 1 | 20% |
| Agricultural and Biological Sciences | 1 | 20% |
| Unknown | 1 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 October 2017.
All research outputs
#15,317,599
of 24,286,850 outputs
Outputs from Bulletin of Mathematical Biology
#664
of 1,158 outputs
Outputs of similar age
#181,292
of 320,812 outputs
Outputs of similar age from Bulletin of Mathematical Biology
#10
of 23 outputs
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