Chapter title |
Endocrine Disruption and In Vitro Ecotoxicology: Recent Advances and Approaches
|
---|---|
Chapter number | 2 |
Book title |
In vitro Environmental Toxicology - Concepts, Application and Assessment
|
Published in |
Advances in biochemical engineering biotechnology, February 2017
|
DOI | 10.1007/10_2016_2 |
Pubmed ID | |
Book ISBNs |
978-3-31-945906-6, 978-3-31-945908-0
|
Authors |
Martin Wagner, Cornelia Kienle, Etiënne L. M. Vermeirssen, Jörg Oehlmann |
Abstract |
Endocrine-disrupting chemicals (EDCs) are man-made compounds interfering with hormone signaling. Omnipresent in the environment, they can cause adverse effects in a wide range of wildlife. Accordingly, Endocrine Disruption is one focal area of ecotoxicology. Because EDCs induce complex response patterns in vivo via a wide range of mechanisms of action, in vitro techniques have been developed to reduce and understand endocrine toxicity. In this review we revisit the evidence for endocrine disruption in diverse species and the underlying molecular mechanisms. Based on this, we examine the battery of in vitro bioassays currently in use in ecotoxicological research and discuss the following key questions. Why do we use in vitro techniques? What endpoints are we looking at? Which applications are we using in vitro bioassays for? How can we put in vitro data into a broader context? And finally, what is the practical relevance of in vitro data? In critically examining these questions, we review the current state-of-the-art of in vitro (eco)toxicology, highlight important limitations and challenges, and discuss emerging trends and future research needs. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Norway | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 54 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 9 | 17% |
Student > Master | 9 | 17% |
Student > Bachelor | 6 | 11% |
Researcher | 5 | 9% |
Student > Doctoral Student | 3 | 6% |
Other | 8 | 15% |
Unknown | 14 | 26% |
Readers by discipline | Count | As % |
---|---|---|
Environmental Science | 10 | 19% |
Agricultural and Biological Sciences | 7 | 13% |
Biochemistry, Genetics and Molecular Biology | 4 | 7% |
Chemistry | 4 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 6% |
Other | 6 | 11% |
Unknown | 20 | 37% |