| Title |
Understanding the focused CD4 T cell response to antigen and pathogenic organisms
|
|---|---|
| Published in |
Immunologic Research, February 2009
|
| DOI | 10.1007/s12026-009-8095-8 |
| Pubmed ID | |
| Authors |
Jason M. Weaver, Andrea J. Sant |
| Abstract |
Immunodominance is a term that reflects the final, very limited peptide specificity of T cells that are elicited during an immune response. Recent experiments in our laboratory compel us to propose a new paradigm for the control of immunodominance in CD4 T cell responses, stating that immunodominance is peptide-intrinsic and is dictated by the off-rate of peptides from MHC class II molecules. Our studies have revealed that persistence of peptide:class II complexes both predicts and controls CD4 T cell immunodominance and that this parameter can be rationally manipulated to either promote or eliminate immune responses. Mechanistically, we have determined that DM editing in APC is a key event that is influenced by the kinetic stability of class II:peptide complexes and that differential persistence of complexes also impacts the expansion phase of the immune response. These studies have important implications for rational vaccine design and for understanding the immunological mechanisms that limit the specificity of CD4 T cell responses. |
Mendeley readers
The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Ireland | 1 | 6% |
| Unknown | 16 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 8 | 47% |
| Researcher | 4 | 24% |
| Professor | 1 | 6% |
| Lecturer > Senior Lecturer | 1 | 6% |
| Professor > Associate Professor | 1 | 6% |
| Other | 0 | 0% |
| Unknown | 2 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 8 | 47% |
| Biochemistry, Genetics and Molecular Biology | 2 | 12% |
| Medicine and Dentistry | 2 | 12% |
| Mathematics | 1 | 6% |
| Immunology and Microbiology | 1 | 6% |
| Other | 1 | 6% |
| Unknown | 2 | 12% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 January 2013.
All research outputs
#20,196,270
of 22,714,025 outputs
Outputs from Immunologic Research
#757
of 905 outputs
Outputs of similar age
#164,369
of 170,074 outputs
Outputs of similar age from Immunologic Research
#5
of 8 outputs
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So far Altmetric has tracked 905 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.0. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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