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Decanalization and the origin of complex disease

Overview of attention for article published in Nature Reviews Genetics, January 2009
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (94th percentile)
  • Good Attention Score compared to outputs of the same age and source (68th percentile)

Mentioned by

news
1 news outlet
policy
1 policy source
twitter
9 X users

Citations

dimensions_citation
253 Dimensions

Readers on

mendeley
273 Mendeley
citeulike
13 CiteULike
connotea
5 Connotea
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Title
Decanalization and the origin of complex disease
Published in
Nature Reviews Genetics, January 2009
DOI 10.1038/nrg2502
Pubmed ID
Authors

Greg Gibson

Abstract

Complex genetic disease is caused by the interaction between genetic and environmental variables and is the predominant cause of mortality globally. Recognition that susceptibility arises through the combination of multiple genetic pathways that influence liability factors in a nonlinear manner suggests that a process of 'decanalization' contributes to the epidemic nature of common genetic diseases. The rapid evolution of the human genome combined with marked environmental and cultural perturbation in the past two generations might lead to the uncovering of cryptic genetic variation that is a major source of disease susceptibility.

X Demographics

X Demographics

The data shown below were collected from the profiles of 9 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 273 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 12 4%
United Kingdom 9 3%
Germany 3 1%
Switzerland 2 <1%
France 2 <1%
Italy 2 <1%
Netherlands 2 <1%
Austria 1 <1%
Sweden 1 <1%
Other 9 3%
Unknown 230 84%

Demographic breakdown

Readers by professional status Count As %
Researcher 77 28%
Student > Ph. D. Student 76 28%
Professor > Associate Professor 22 8%
Student > Bachelor 18 7%
Student > Master 17 6%
Other 45 16%
Unknown 18 7%
Readers by discipline Count As %
Agricultural and Biological Sciences 145 53%
Biochemistry, Genetics and Molecular Biology 34 12%
Medicine and Dentistry 30 11%
Psychology 8 3%
Computer Science 7 3%
Other 25 9%
Unknown 24 9%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 17. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 February 2021.
All research outputs
#2,174,109
of 25,371,288 outputs
Outputs from Nature Reviews Genetics
#950
of 2,725 outputs
Outputs of similar age
#9,290
of 183,446 outputs
Outputs of similar age from Nature Reviews Genetics
#6
of 19 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,725 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 32.3. This one has gotten more attention than average, scoring higher than 65% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 183,446 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 19 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.