| Title |
Effects of aging on T1, T2∗, and QSM MRI values in the subcortex
|
|---|---|
| Published in |
Brain Structure and Function, February 2017
|
| DOI | 10.1007/s00429-016-1352-4 |
| Pubmed ID | |
| Authors |
M. C. Keuken, P.-L. Bazin, K. Backhouse, S. Beekhuizen, L. Himmer, A. Kandola, J. J. Lafeber, L. Prochazkova, A. Trutti, A. Schäfer, R. Turner, B. U. Forstmann |
| Abstract |
The aging brain undergoes several anatomical changes that can be measured with Magnetic Resonance Imaging (MRI). Early studies using lower field strengths have assessed changes in tissue properties mainly qualitatively, using [Formula: see text]- or [Formula: see text]- weighted images to provide image contrast. With the development of higher field strengths (7 T and above) and more advanced MRI contrasts, quantitative measures can be acquired even of small subcortical structures. This study investigates volumetric, spatial, and quantitative MRI parameter changes associated with healthy aging in a range of subcortical nuclei, including the basal ganglia, red nucleus, and the periaqueductal grey. The results show that aging has a heterogenous effects across regions. Across the subcortical areas an increase of [Formula: see text] values is observed, most likely indicating a loss of myelin. Only for a number of areas, a decrease of [Formula: see text] and increase of QSM is found, indicating an increase of iron. Aging also results in a location shift for a number of structures indicating the need for visualization of the anatomy of individual brains. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 103 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | <1% |
| Unknown | 102 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 29 | 28% |
| Researcher | 21 | 20% |
| Student > Master | 11 | 11% |
| Student > Bachelor | 9 | 9% |
| Student > Postgraduate | 6 | 6% |
| Other | 14 | 14% |
| Unknown | 13 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 24 | 23% |
| Medicine and Dentistry | 17 | 17% |
| Psychology | 9 | 9% |
| Engineering | 6 | 6% |
| Physics and Astronomy | 6 | 6% |
| Other | 15 | 15% |
| Unknown | 26 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 February 2017.
All research outputs
#16,454,538
of 24,217,893 outputs
Outputs from Brain Structure and Function
#1,015
of 1,725 outputs
Outputs of similar age
#264,929
of 427,421 outputs
Outputs of similar age from Brain Structure and Function
#19
of 33 outputs
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