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Neurocognitive Predictors of Response in Treatment Resistant Depression to Subcallosal Cingulate Gyrus Deep Brain Stimulation

Overview of attention for article published in Frontiers in Human Neuroscience, February 2017
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Title
Neurocognitive Predictors of Response in Treatment Resistant Depression to Subcallosal Cingulate Gyrus Deep Brain Stimulation
Published in
Frontiers in Human Neuroscience, February 2017
DOI 10.3389/fnhum.2017.00074
Pubmed ID
Authors

Shane J. McInerney, Heather E. McNeely, Joseph Geraci, Peter Giacobbe, Sakina J. Rizvi, Amanda K. Ceniti, Anna Cyriac, Helen S. Mayberg, Andres M. Lozano, Sidney H. Kennedy

Abstract

Background: Deep brain stimulation (DBS) is a neurosurgical intervention with demonstrated effectiveness for treatment resistant depression (TRD), but longitudinal studies on the stability of cognitive parameters following treatment are limited. The objectives of this study are to (i) identify baseline cognitive predictors of treatment response to subcallosal cingulate gyrus (SCG) DBS for unipolar TRD and (ii) compare neurocognitive performance prior to and 12 months after DBS implantation. Methods: Twenty unipolar TRD patients received SCG DBS for 12 months. A standardized neuropsychological battery was used to assess a range of neurocognitive abilities at baseline and after 12 months. Severity of depression was evaluated using the 17 item Hamilton Rating Scale for Depression. Results: Finger Tap-Dominant Hand Test and total number of errors made on the Wisconsin Card Sorting Test predicted classification of patients as treatment responders or non-responders, and were independent of improvement in mood. Change in verbal fluency was the only neuropsychological test that correlated with change in mood from baseline to the follow up period. None of the neuropsychological measures displayed deterioration in cognitive functioning from baseline to repeat testing at 12 months. Limitations: This was an open label study with a small sample size which limits predictive analysis. Practice effects of the neuropsychological testing could explain the improvement from baseline to follow up on some tasks. Replication using a larger sample of subjects who received neuropsychological testing before and at least 12 months after DBS surgery is required. Conclusion: These preliminary results (i) suggest that psychomotor speed may be a useful baseline predictor of response to SCG DBS treatment and (ii) support previous suggestions that SCG DBS has no deleterious effects on cognition.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 101 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Canada 1 <1%
Unknown 100 99%

Demographic breakdown

Readers by professional status Count As %
Researcher 15 15%
Student > Bachelor 14 14%
Student > Master 10 10%
Student > Ph. D. Student 9 9%
Other 6 6%
Other 19 19%
Unknown 28 28%
Readers by discipline Count As %
Psychology 21 21%
Medicine and Dentistry 19 19%
Neuroscience 11 11%
Agricultural and Biological Sciences 2 2%
Computer Science 2 2%
Other 10 10%
Unknown 36 36%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 February 2017.
All research outputs
#13,460,409
of 22,952,268 outputs
Outputs from Frontiers in Human Neuroscience
#3,987
of 7,179 outputs
Outputs of similar age
#161,215
of 311,628 outputs
Outputs of similar age from Frontiers in Human Neuroscience
#123
of 197 outputs
Altmetric has tracked 22,952,268 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 7,179 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.6. This one is in the 43rd percentile – i.e., 43% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 311,628 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 197 others from the same source and published within six weeks on either side of this one. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.