| Title |
Associations between chronic comorbidity and exacerbation risk in primary care patients with COPD
|
|---|---|
| Published in |
Respiratory Research, February 2017
|
| DOI | 10.1186/s12931-017-0512-2 |
| Pubmed ID | |
| Authors |
Janine A. M. Westerik, Esther I. Metting, Job F. M. van Boven, Waling Tiersma, Janwillem W. H. Kocks, Tjard R. Schermer |
| Abstract |
COPD often coexists with chronic conditions that may influence disease prognosis. We investigated associations between chronic (co)morbidities and exacerbations in primary care COPD patients. Retrospective cohort study based on 2012-2013 electronic health records from 179 Dutch general practices. Comorbidities from patients with physician-diagnosed COPD were categorized according to International Classification of Primary Care (ICPC) codes. Chi-squared tests, uni- and multivariable logistic, and Cox regression analyses were used to study associations with exacerbations, defined as oral corticosteroid prescriptions. Fourteen thousand six hundred three patients with COPD could be studied (mean age 67 (SD 12) years, 53% male) for two years. At baseline 12,826 (88%) suffered from ≥1 comorbidities, 3263 (22%) from ≥5. The most prevalent comorbidities were hypertension (35%), coronary heart disease (19%), and osteoarthritis (18%). Several comorbidities showed statistically significant associations with frequent (i.e., ≥2/year) exacerbations: heart failure (odds ratio [OR], 95% confidence interval: 1.72; 1.38-2.14), blindness & low vision (OR 1.46; 1.21-1.75), pulmonary cancer (OR 1.85; 1.28-2.67), depression 1.48; 1.14-1.91), prostate disorders (OR 1.50; 1.13-1.98), asthma (OR 1.36; 1.11-1.70), osteoporosis (OR 1.41; 1.11-1.80), diabetes (OR 0.80; 0.66-0.97), dyspepsia (OR 1.25; 1.03-1.50), and peripheral vascular disease (OR 1.20; 1.00-1.45). From all comorbidity categories, having another chronic respiratory disease beside COPD showed the highest risk for developing a new exacerbation (Cox hazard ratio 1.26; 1.17-1.36). Chronic comorbidities are highly prevalent in primary care COPD patients. Several chronic comorbidities were associated with having frequent exacerbations and increased exacerbation risk. |
X Demographics
The data shown below were collected from the profiles of 45 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 11 | 24% |
| Spain | 2 | 4% |
| Australia | 1 | 2% |
| Saudi Arabia | 1 | 2% |
| Indonesia | 1 | 2% |
| United States | 1 | 2% |
| India | 1 | 2% |
| Brazil | 1 | 2% |
| Argentina | 1 | 2% |
| Other | 6 | 13% |
| Unknown | 19 | 42% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 29 | 64% |
| Practitioners (doctors, other healthcare professionals) | 8 | 18% |
| Scientists | 6 | 13% |
| Science communicators (journalists, bloggers, editors) | 2 | 4% |
Mendeley readers
The data shown below were compiled from readership statistics for 165 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 165 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 23 | 14% |
| Researcher | 22 | 13% |
| Student > Master | 17 | 10% |
| Student > Ph. D. Student | 13 | 8% |
| Student > Doctoral Student | 10 | 6% |
| Other | 30 | 18% |
| Unknown | 50 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 62 | 38% |
| Nursing and Health Professions | 14 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 7 | 4% |
| Biochemistry, Genetics and Molecular Biology | 6 | 4% |
| Psychology | 4 | 2% |
| Other | 15 | 9% |
| Unknown | 57 | 35% |
Attention Score in Context
This research output has an Altmetric Attention Score of 31. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 December 2018.
All research outputs
#1,268,656
of 25,382,440 outputs
Outputs from Respiratory Research
#93
of 3,062 outputs
Outputs of similar age
#27,020
of 424,791 outputs
Outputs of similar age from Respiratory Research
#2
of 53 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,062 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.9. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 424,791 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 53 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.