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X Demographics
Mendeley readers
Attention Score in Context
| Title |
An Evolutionarily Conserved SoxB-Hdac2 Crosstalk Regulates Neurogenesis in a Cnidarian
|
|---|---|
| Published in |
Cell Reports, February 2017
|
| DOI | 10.1016/j.celrep.2017.01.019 |
| Pubmed ID | |
| Authors |
Hakima Flici, Christine E. Schnitzler, R. Cathriona Millane, Graham Govinden, Amy Houlihan, Stephanie D. Boomkamp, Sanbing Shen, Andreas D. Baxevanis, Uri Frank |
| Abstract |
SoxB transcription factors and histone deacetylases (HDACs) are each major players in the regulation of neurogenesis, but a functional link between them has not been previously demonstrated. Here, we show that SoxB2 and Hdac2 act together to regulate neurogenesis in the cnidarian Hydractinia echinata during tissue homeostasis and head regeneration. We find that misexpression of SoxB genes modifies the number of neural cells in all life stages and interferes with head regeneration. Hdac2 was co-expressed with SoxB2, and its downregulation phenocopied SoxB2 knockdown. We also show that SoxB2 and Hdac2 promote each other's transcript levels, but Hdac2 counteracts this amplification cycle by deacetylating and destabilizing SoxB2 protein. Finally, we present evidence for conservation of these interactions in human neural progenitors. We hypothesize that crosstalk between SoxB transcription factors and Hdac2 is an ancient feature of metazoan neurogenesis and functions to stabilize the correct levels of these multifunctional proteins. |
X Demographics
The data shown below were collected from the profiles of 20 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 9 | 45% |
| France | 1 | 5% |
| Canada | 1 | 5% |
| Israel | 1 | 5% |
| Norway | 1 | 5% |
| Ireland | 1 | 5% |
| Unknown | 6 | 30% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 9 | 45% |
| Members of the public | 8 | 40% |
| Practitioners (doctors, other healthcare professionals) | 2 | 10% |
| Science communicators (journalists, bloggers, editors) | 1 | 5% |
Mendeley readers
The data shown below were compiled from readership statistics for 52 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 52 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 21 | 40% |
| Student > Bachelor | 10 | 19% |
| Researcher | 9 | 17% |
| Professor | 2 | 4% |
| Other | 2 | 4% |
| Other | 4 | 8% |
| Unknown | 4 | 8% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 20 | 38% |
| Agricultural and Biological Sciences | 16 | 31% |
| Medicine and Dentistry | 4 | 8% |
| Neuroscience | 3 | 6% |
| Immunology and Microbiology | 1 | 2% |
| Other | 1 | 2% |
| Unknown | 7 | 13% |
Attention Score in Context
This research output has an Altmetric Attention Score of 19. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 July 2017.
All research outputs
#1,915,508
of 25,382,440 outputs
Outputs from Cell Reports
#4,351
of 12,965 outputs
Outputs of similar age
#39,431
of 424,972 outputs
Outputs of similar age from Cell Reports
#93
of 262 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 12,965 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 30.3. This one has gotten more attention than average, scoring higher than 66% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 424,972 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 262 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.