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Food, Nutrigenomics, and Neurodegeneration—Neuroprotection by What You Eat!

Overview of attention for article published in Molecular Neurobiology, June 2013
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (91st percentile)
  • High Attention Score compared to outputs of the same age and source (85th percentile)

Mentioned by

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15 X users
facebook
10 Facebook pages
wikipedia
1 Wikipedia page
googleplus
2 Google+ users

Citations

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116 Dimensions

Readers on

mendeley
244 Mendeley
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Title
Food, Nutrigenomics, and Neurodegeneration—Neuroprotection by What You Eat!
Published in
Molecular Neurobiology, June 2013
DOI 10.1007/s12035-013-8498-3
Pubmed ID
Authors

Ashraf Virmani, Luigi Pinto, Zbigniew Binienda, Syed Ali

Abstract

Diet in human health is no longer simple nutrition, but in light of recent research, especially nutrigenomics, it is linked via evolution and genetics to cell health status capable of modulating apoptosis, detoxification, and appropriate gene response. Nutritional deficiency and disease especially lack of vitamins and minerals is well known, but more recently, epidemiological studies suggest a role of fruits and vegetables, as well as essential fatty acids and even red wine (French paradox), in protection against disease. In the early 1990s, various research groups started considering the use of antioxidants (e.g., melatonin, resveratrol, green tea, lipoic acid) and metabolic compounds (e.g., nicotinamide, acetyl-L-carnitine, creatine, coenzyme Q10) as possible candidates in neuroprotection. They were of course considered on par with snake oil salesman (women) at the time. The positive actions of nutritional supplements, minerals, and plant extracts in disease prevention are now mainstream and commercial health claims being made are subject to regulation in most countries. Apart from efficacy and finding, the right dosages, the safety, and especially the level of purification and lack of contamination are all issues that are important as their use becomes widespread. From the mechanistic point of view, most of the time these substances replenish the body's deficiency and restore normal function. However, they also exert actions that are not sensu stricto nutritive and could be considered pharmacological especially that, at times, higher intake than recommended (RDA) is needed to see these effects. Free radicals and neuroinflammation processes underlie many neurodegenerative conditions, even Parkinson's disease and Alzheimer's disease. Curcumin, carotenoids, acetyl-L-carnitine, coenzyme Q10, vitamin D, and polyphenols and other nutraceuticals have the potential to target multiple pathways in these conditions. In summary, augmenting neuroprotective pathways using diet and finding new natural substances that can be more efficacious, i.e., induction of health-promoting genes and reduction of the expression of disease-promoting genes, could be incorporated into neuroprotective strategies of the future.

X Demographics

X Demographics

The data shown below were collected from the profiles of 15 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 244 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 3 1%
United Kingdom 2 <1%
Switzerland 1 <1%
Italy 1 <1%
Egypt 1 <1%
Bangladesh 1 <1%
Japan 1 <1%
United States 1 <1%
Unknown 233 95%

Demographic breakdown

Readers by professional status Count As %
Student > Master 45 18%
Student > Bachelor 31 13%
Researcher 28 11%
Student > Ph. D. Student 23 9%
Other 17 7%
Other 50 20%
Unknown 50 20%
Readers by discipline Count As %
Agricultural and Biological Sciences 49 20%
Medicine and Dentistry 45 18%
Biochemistry, Genetics and Molecular Biology 18 7%
Neuroscience 16 7%
Nursing and Health Professions 12 5%
Other 45 18%
Unknown 59 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 17. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 December 2020.
All research outputs
#1,797,766
of 22,714,025 outputs
Outputs from Molecular Neurobiology
#153
of 3,433 outputs
Outputs of similar age
#16,434
of 195,450 outputs
Outputs of similar age from Molecular Neurobiology
#4
of 28 outputs
Altmetric has tracked 22,714,025 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,433 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 195,450 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 28 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 85% of its contemporaries.