| Title |
Autoantibodies to Variable Heavy (VH) Chain Ig Sequences in Humans Impact the Safety and Clinical Pharmacology of a VH Domain Antibody Antagonist of TNF-α Receptor 1
|
|---|---|
| Published in |
Journal of Clinical Immunology, July 2013
|
| DOI | 10.1007/s10875-013-9915-0 |
| Pubmed ID | |
| Authors |
M. C. Holland, J. U. Wurthner, P. J. Morley, M. A. Birchler, J. Lambert, M. Albayaty, A. P. Serone, R. Wilson, Y. Chen, R. M Forrest, J. C. Cordy, D. A. Lipson, A. I. Bayliffe |
| Abstract |
To investigate the impact of a new class of anti-Ig autoantibodies reactive with variable heavy (VH) chain framework sequences (human anti-VH autoantibodies) on the pharmacology and safety of an anti-TNFR1 VH domain antibody (GSK1995057) in healthy human subjects. |
Mendeley readers
The data shown below were compiled from readership statistics for 76 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 76 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 21 | 28% |
| Student > Ph. D. Student | 11 | 14% |
| Other | 10 | 13% |
| Student > Master | 7 | 9% |
| Student > Doctoral Student | 4 | 5% |
| Other | 6 | 8% |
| Unknown | 17 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 16 | 21% |
| Agricultural and Biological Sciences | 13 | 17% |
| Medicine and Dentistry | 9 | 12% |
| Immunology and Microbiology | 7 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 7% |
| Other | 5 | 7% |
| Unknown | 21 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 October 2023.
All research outputs
#2,524,403
of 23,556,846 outputs
Outputs from Journal of Clinical Immunology
#121
of 1,622 outputs
Outputs of similar age
#22,047
of 195,957 outputs
Outputs of similar age from Journal of Clinical Immunology
#1
of 11 outputs
Altmetric has tracked 23,556,846 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,622 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 195,957 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.