| Title |
High-Resolution fMRI of Auditory Cortical Map Changes in Unilateral Hearing Loss and Tinnitus
|
|---|---|
| Published in |
Brain Topography, February 2017
|
| DOI | 10.1007/s10548-017-0547-1 |
| Pubmed ID | |
| Authors |
Naghmeh Ghazaleh, Wietske van der Zwaag, Stephanie Clarke, Dimitri Van De Ville, Raphael Maire, Melissa Saenz |
| Abstract |
Animal models of hearing loss and tinnitus observe pathological neural activity in the tonotopic frequency maps of the primary auditory cortex. Here, we applied ultra high-field fMRI at 7 T to test whether human patients with unilateral hearing loss and tinnitus also show altered functional activity in the primary auditory cortex. The high spatial resolution afforded by 7 T imaging allowed tonotopic mapping of primary auditory cortex on an individual subject basis. Eleven patients with unilateral hearing loss and tinnitus were compared to normal-hearing controls. Patients showed an over-representation and hyperactivity in a region of the cortical map corresponding to low frequencies sounds, irrespective of the hearing loss and tinnitus range, which in most cases affected higher frequencies. This finding of hyperactivity in low frequency map regions, irrespective of hearing loss range, is consistent with some previous studies in animal models and corroborates a previous study of human tinnitus. Thus these findings contribute to accumulating evidence that gross cortical tonotopic map reorganization is not a causal factor of tinnitus. |
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 50 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 12 | 24% |
| Researcher | 9 | 18% |
| Student > Ph. D. Student | 8 | 16% |
| Student > Doctoral Student | 5 | 10% |
| Student > Bachelor | 2 | 4% |
| Other | 2 | 4% |
| Unknown | 12 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 10 | 20% |
| Neuroscience | 9 | 18% |
| Engineering | 4 | 8% |
| Nursing and Health Professions | 3 | 6% |
| Physics and Astronomy | 2 | 4% |
| Other | 5 | 10% |
| Unknown | 17 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 February 2017.
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#18,530,362
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Outputs from Brain Topography
#356
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Outputs of similar age
#310,511
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Outputs of similar age from Brain Topography
#11
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