| Title |
Cholestasis induces reversible accumulation of periplakin in mouse liver
|
|---|---|
| Published in |
BMC Gastroenterology, July 2013
|
| DOI | 10.1186/1471-230x-13-116 |
| Pubmed ID | |
| Authors |
Shinji Ito, Junko Satoh, Tsutomu Matsubara, Yatrik M Shah, Sung-hoon Ahn, Cherie R Anderson, Weiwei Shan, Jeffrey M Peters, Frank J Gonzalez |
| Abstract |
Periplakin (PPL) is a rod-shaped cytolinker protein thought to connect cellular adhesion junctional complexes to cytoskeletal filaments. PPL serves as a structural component of the cornified envelope in the skin and interacts with various types of proteins in cultured cells; its level decreases dramatically during tumorigenic progression in human epithelial tissues. Despite these intriguing observations, the physiological roles of PPL, especially in non-cutaneous tissues, are still largely unknown. Because we observed a marked fluctuation of PPL expression in mouse liver in association with the bile acid receptor farnesoid X receptor (FXR) and cholestasis, we sought to characterize the role of PPL in the liver and determine its contributions to the etiology and pathogenesis of cholestasis. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 8 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 8 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Professor > Associate Professor | 2 | 25% |
| Other | 1 | 13% |
| Student > Master | 1 | 13% |
| Unknown | 4 | 50% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 1 | 13% |
| Chemistry | 1 | 13% |
| Medicine and Dentistry | 1 | 13% |
| Unknown | 5 | 63% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 July 2013.
All research outputs
#18,341,711
of 22,714,025 outputs
Outputs from BMC Gastroenterology
#1,130
of 1,731 outputs
Outputs of similar age
#145,809
of 194,284 outputs
Outputs of similar age from BMC Gastroenterology
#12
of 20 outputs
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