| Title |
Flow-dependent concentration polarization and the endothelial glycocalyx layer: multi-scale aspects of arterial mass transport and their implications for atherosclerosis
|
|---|---|
| Published in |
Biomechanics and Modeling in Mechanobiology, July 2013
|
| DOI | 10.1007/s10237-013-0512-1 |
| Pubmed ID | |
| Authors |
P. E. Vincent, P. D. Weinberg |
| Abstract |
Atherosclerosis is the underlying cause of most heart attacks and strokes. It is thereby the leading cause of death in the Western world, and it places a significant financial burden on health care systems. There is evidence that complex, multi-scale arterial mass transport processes play a key role in the development of atherosclerosis. Such processes can be controlled both by blood flow patterns and by properties of the arterial wall. This short review focuses on one vascular-scale, flow-regulated arterial mass transport process, namely concentration polarization of low density lipoprotein at the luminal surface of the arterial endothelium, and on one cellular-scale, structural determinant of arterial wall mass transport, namely the endothelial glycocalyx layer. Both have attracted significant attention in recent years. In addition to reviewing and appraising relevant literature, we propose various directions for future work. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 38 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 3% |
| Czechia | 1 | 3% |
| Unknown | 36 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 10 | 26% |
| Researcher | 7 | 18% |
| Student > Doctoral Student | 4 | 11% |
| Student > Bachelor | 4 | 11% |
| Student > Master | 3 | 8% |
| Other | 4 | 11% |
| Unknown | 6 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Engineering | 12 | 32% |
| Medicine and Dentistry | 6 | 16% |
| Agricultural and Biological Sciences | 6 | 16% |
| Biochemistry, Genetics and Molecular Biology | 2 | 5% |
| Business, Management and Accounting | 2 | 5% |
| Other | 4 | 11% |
| Unknown | 6 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 July 2013.
All research outputs
#16,069,695
of 23,849,058 outputs
Outputs from Biomechanics and Modeling in Mechanobiology
#285
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Outputs of similar age
#122,657
of 196,522 outputs
Outputs of similar age from Biomechanics and Modeling in Mechanobiology
#4
of 5 outputs
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