| Title |
IL-1 and T Helper Immune Responses
|
|---|---|
| Published in |
Frontiers in immunology, January 2013
|
| DOI | 10.3389/fimmu.2013.00182 |
| Pubmed ID | |
| Authors |
Veronica Santarlasci, Lorenzo Cosmi, Laura Maggi, Francesco Liotta, Francesco Annunziato |
| Abstract |
CD4 T cells play a critical role in mediating adaptive immunity to a variety of pathogens as well as in tumor immunity. If not adequately regulated, CD4 T cells can be also involved in autoimmunity, asthma, and allergic responses. During TCR activation in a particular cytokine milieu, naïve CD4 T cells may differentiate into one of several lineages of T helper (Th) cells, including Th1, Th2, and Th17, as defined by their pattern of cytokine production and function. IL-1, the prototypic proinflammatory cytokine, has been shown to influence growth and differentiation of immunocompetent lymphocytes. The differential expression of IL-1RI on human CD4 T cell subsets confers distinct capacities to acquire specific effector functions. In this review, we summarize the role of IL-1 on CD4 T cells, in terms of differentiation, activation, and maintenance or survival. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Switzerland | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 165 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 165 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 44 | 27% |
| Student > Master | 23 | 14% |
| Student > Bachelor | 22 | 13% |
| Researcher | 20 | 12% |
| Student > Doctoral Student | 9 | 5% |
| Other | 11 | 7% |
| Unknown | 36 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 35 | 21% |
| Immunology and Microbiology | 27 | 16% |
| Medicine and Dentistry | 23 | 14% |
| Biochemistry, Genetics and Molecular Biology | 20 | 12% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 3% |
| Other | 16 | 10% |
| Unknown | 39 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 May 2020.
All research outputs
#7,988,027
of 25,932,719 outputs
Outputs from Frontiers in immunology
#9,388
of 32,608 outputs
Outputs of similar age
#79,191
of 291,797 outputs
Outputs of similar age from Frontiers in immunology
#94
of 503 outputs
Altmetric has tracked 25,932,719 research outputs across all sources so far. This one has received more attention than most of these and is in the 68th percentile.
So far Altmetric has tracked 32,608 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.5. This one has gotten more attention than average, scoring higher than 70% of its peers.
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We're also able to compare this research output to 503 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.