| Title |
Endogenous Neural Stem Cells in the Adult Brain
|
|---|---|
| Published in |
Journal of Neuroimmune Pharmacology, May 2007
|
| DOI | 10.1007/s11481-007-9076-0 |
| Pubmed ID | |
| Authors |
Kunlin Jin, Veronica Galvan |
| Abstract |
Despite progress in our understanding molecular mechanisms of neuronal cell death in many central nervous system (CNS) diseases, widely effective treatments remain elusive. Recent studies have shown that neural stem cells (NSCs) are present in the subventricular zone (SVZ) lining the lateral ventricles and the subgranular zone (SGZ) of the hippocampal dentate gyrus (DG) in adult mouse, rat, nonhuman primate, and human brain. Newly generated cells in the SGZ can differentiate into mature, functional neurons and integrate into the DG as granule cells, which are involved in memory formation. In addition, many CNS diseases can stimulate the proliferation of neuronal stem/progenitor cells located in the SVZ and SGZ of the adult rodent brain, and the resulting newborn cells migrate into damaged brain regions, where they express mature neuronal markers. Therefore, it might be possible for damaged cells to be replaced from endogenous neural stem cell pools. However, the capacity of self-repair is obviously not enough. Proliferation, migration, and neuronal differentiation of endogenous NSCs could be manipulated by pharmaceutical tools to reach the adequate benefits for the treatment of CNS diseases. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 62 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 6% |
| Portugal | 1 | 2% |
| Czechia | 1 | 2% |
| Switzerland | 1 | 2% |
| United Kingdom | 1 | 2% |
| Luxembourg | 1 | 2% |
| Unknown | 53 | 85% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 16 | 26% |
| Researcher | 11 | 18% |
| Student > Master | 8 | 13% |
| Student > Bachelor | 5 | 8% |
| Professor > Associate Professor | 5 | 8% |
| Other | 9 | 15% |
| Unknown | 8 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 20 | 32% |
| Medicine and Dentistry | 17 | 27% |
| Biochemistry, Genetics and Molecular Biology | 4 | 6% |
| Neuroscience | 3 | 5% |
| Linguistics | 1 | 2% |
| Other | 4 | 6% |
| Unknown | 13 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 December 2022.
All research outputs
#3,203,383
of 24,217,893 outputs
Outputs from Journal of Neuroimmune Pharmacology
#86
of 583 outputs
Outputs of similar age
#7,521
of 73,361 outputs
Outputs of similar age from Journal of Neuroimmune Pharmacology
#1
of 4 outputs
Altmetric has tracked 24,217,893 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 583 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.7. This one has done well, scoring higher than 84% of its peers.
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We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them