Title |
Endocrine Disrupting Activities of the Flavonoid Nutraceuticals Luteolin and Quercetin
|
---|---|
Published in |
Discover Oncology, July 2013
|
DOI | 10.1007/s12672-013-0150-1 |
Pubmed ID | |
Authors |
Steven K. Nordeen, Betty J. Bona, David N. Jones, James R. Lambert, Twila A. Jackson |
Abstract |
Dietary plant flavonoids have been proposed to contribute to cancer prevention, neuroprotection, and cardiovascular health through their anti-oxidant, anti-inflammatory, pro-apoptotic, and antiproliferative activities. As a consequence, flavonoid supplements are aggressively marketed by the nutraceutical industry for many purposes, including pediatric applications, despite inadequate understanding of their value and drawbacks. We show that two flavonoids, luteolin and quercetin, are promiscuous endocrine disruptors. These flavonoids display progesterone antagonist activity beneficial in a breast cancer model but deleterious in an endometrial cancer model. Concurrently, luteolin possesses potent estrogen agonist activity while quercetin is considerably less effective. These results highlight the promise and peril of flavonoid nutraceuticals and suggest caution in supplementation beyond levels attained in a healthy, plant-rich diet. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 10% |
Spain | 1 | 10% |
Canada | 1 | 10% |
Australia | 1 | 10% |
Unknown | 6 | 60% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 7 | 70% |
Practitioners (doctors, other healthcare professionals) | 3 | 30% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 66 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 13 | 20% |
Student > Ph. D. Student | 7 | 11% |
Researcher | 4 | 6% |
Student > Doctoral Student | 4 | 6% |
Student > Bachelor | 3 | 5% |
Other | 10 | 15% |
Unknown | 25 | 38% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 10 | 15% |
Agricultural and Biological Sciences | 8 | 12% |
Chemistry | 8 | 12% |
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 8% |
Biochemistry, Genetics and Molecular Biology | 4 | 6% |
Other | 4 | 6% |
Unknown | 27 | 41% |