↓ Skip to main content

Axon position within the corpus callosum determines contralateral cortical projection

Overview of attention for article published in Proceedings of the National Academy of Sciences of the United States of America, June 2013
Altmetric Badge

About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (84th percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

blogs
1 blog
twitter
2 X users
f1000
1 research highlight platform

Citations

dimensions_citation
85 Dimensions

Readers on

mendeley
221 Mendeley
citeulike
1 CiteULike
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Axon position within the corpus callosum determines contralateral cortical projection
Published in
Proceedings of the National Academy of Sciences of the United States of America, June 2013
DOI 10.1073/pnas.1310233110
Pubmed ID
Authors

Jing Zhou, Yunqing Wen, Liang She, Ya-nan Sui, Lu Liu, Linda J. Richards, Mu-ming Poo

Abstract

How developing axons in the corpus callosum (CC) achieve their homotopic projection to the contralateral cortex remains unclear. We found that axonal position within the CC plays a critical role in this projection. Labeling of nearby callosal axons in mice showed that callosal axons were segregated in an orderly fashion, with those from more medial cerebral cortex located more dorsally and subsequently projecting to more medial contralateral cortical regions. The normal axonal order within the CC was grossly disturbed when semaphorin3A/neuropilin-1 signaling was disrupted. However, the order in which axons were positioned within the CC still determined their contralateral projection, causing a severe disruption of the homotopic contralateral projection that persisted at postnatal day 30, when the normal developmental refinement of contralateral projections is completed in wild-type (WT) mice. Thus, the orderly positioning of axons within the CC is a primary determinant of how homotopic interhemispheric projections form in the contralateral cortex.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 221 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 1%
France 2 <1%
Japan 2 <1%
China 1 <1%
Switzerland 1 <1%
Israel 1 <1%
Poland 1 <1%
Unknown 210 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 63 29%
Researcher 34 15%
Student > Bachelor 20 9%
Student > Master 14 6%
Professor > Associate Professor 12 5%
Other 41 19%
Unknown 37 17%
Readers by discipline Count As %
Neuroscience 68 31%
Agricultural and Biological Sciences 55 25%
Medicine and Dentistry 22 10%
Biochemistry, Genetics and Molecular Biology 14 6%
Psychology 4 2%
Other 19 9%
Unknown 39 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 June 2014.
All research outputs
#3,914,244
of 24,625,114 outputs
Outputs from Proceedings of the National Academy of Sciences of the United States of America
#36,641
of 101,438 outputs
Outputs of similar age
#30,276
of 200,035 outputs
Outputs of similar age from Proceedings of the National Academy of Sciences of the United States of America
#507
of 983 outputs
Altmetric has tracked 24,625,114 research outputs across all sources so far. Compared to these this one has done well and is in the 84th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 101,438 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 38.8. This one has gotten more attention than average, scoring higher than 59% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 200,035 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 983 others from the same source and published within six weeks on either side of this one. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.