| Title |
The Effect of Oral α-Galactosidase on Intestinal Gas Production and Gas-Related Symptoms
|
|---|---|
| Published in |
Digestive Diseases and Sciences, December 2006
|
| DOI | 10.1007/s10620-006-9296-9 |
| Pubmed ID | |
| Authors |
Michele Di Stefano, Emanuela Miceli, Samantha Gotti, Antonio Missanelli, Samanta Mazzocchi, Gino Roberto Corazza |
| Abstract |
Bloating, abdominal distention, and flatulence represent very frequent complaints in functional disorders but their pathophysiology and treatment are largely unknown. Patients frequently associate these symptoms with excessive intestinal gas and the reduction of gas production may represent an effective strategy. The aim was to evaluate the effect of alpha-galactosidase administration, in a randomized double-blind placebo-controlled protocol, on intestinal gas production and gas-related symptoms after a challenge test meal in healthy volunteers. Eight healthy volunteers ingested 300 or 1200 GalU of alpha-galactosidase or placebo during a test meal containing 420 g of cooked beans. Breath hydrogen excretion and occurrence of bloating, abdominal pain, discomfort, flatulence, and diarrhea were measured for 8 hr. The administration of 1200 GalU of alpha-galactosidase induced a significant reduction of both breath hydrogen excretion and severity of flatulence. A reduction in severity was apparent for all considered symptoms, but both 300 and 1200 GalU induced a significant reduction in the total symptom score. Alpha-galactosidase reduced gas production following a meal rich in fermentable carbohydrates and may be helpful in patients with gas-related symptoms. |
X Demographics
The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 50% |
| France | 1 | 17% |
| Curaçao | 1 | 17% |
| Unknown | 1 | 17% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 67% |
| Scientists | 2 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 93 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 1% |
| Unknown | 92 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 18 | 19% |
| Researcher | 13 | 14% |
| Other | 10 | 11% |
| Student > Bachelor | 9 | 10% |
| Student > Ph. D. Student | 8 | 9% |
| Other | 15 | 16% |
| Unknown | 20 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 16 | 17% |
| Medicine and Dentistry | 16 | 17% |
| Biochemistry, Genetics and Molecular Biology | 10 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 7 | 8% |
| Nursing and Health Professions | 5 | 5% |
| Other | 14 | 15% |
| Unknown | 25 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 90. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 March 2024.
All research outputs
#481,239
of 25,703,943 outputs
Outputs from Digestive Diseases and Sciences
#34
of 4,699 outputs
Outputs of similar age
#938
of 170,159 outputs
Outputs of similar age from Digestive Diseases and Sciences
#1
of 34 outputs
Altmetric has tracked 25,703,943 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,699 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.1. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 170,159 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 34 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.