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Mendeley readers
Attention Score in Context
| Title |
Polyvinyl alcohol composite nanofibres containing conjugated levofloxacin-chitosan for controlled drug release
|
|---|---|
| Published in |
Materials Science & Engineering: C, December 2016
|
| DOI | 10.1016/j.msec.2016.12.112 |
| Pubmed ID | |
| Authors |
Javid Jalvandi, Max White, Yuan Gao, Yen Bach Truong, Rajiv Padhye, Ilias Louis Kyratzis |
| Abstract |
A range of biodegradable drug-nanofibres composite mats have been reported as drug delivery systems. However, their main disadvantage is the rapid release of the drug immediately after application. This paper reports an improved system based on the incorporation of drug conjugated-chitosan into polyvinyl alcohol (PVA) nanofibers. The results showed that controlled release of levofloxacin (LVF) could be achieved by covalently binding LVF to low molecular weight chitosan (CS) via a cleavable amide bond and then blending the conjugated CS with polyvinyl alcohol (PVA) nanofibres prior to electrospinning. PVA/LVF and PVA-CS/LVF nanofibres were fabricated as controls. The conjugated CS-LVF was characterized by FTIR, DSC, TGA and (1)H NMR. Scanning electron microscopy (SEM) showed that the blended CS-PVA nanofibres had a reduced fibre diameter compared to the controls. Drug release profiles showed that burst release was decreased from 90% in the control PVA/LVF electrospun mats to 27% in the PVA/conjugated CS-LVF mats after 8h in phosphate buffer at 37°C. This slower release is due to the cleavable bond between LVF and CS that slowly hydrolysed over time at neutral pH. The results indicate that conjugation of the drug to the polymer backbone is an effective way of minimizing burst release behaviour and achieving sustained release of the drug, LVF. |
Mendeley readers
The data shown below were compiled from readership statistics for 112 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 112 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 17 | 15% |
| Student > Ph. D. Student | 15 | 13% |
| Researcher | 13 | 12% |
| Student > Bachelor | 10 | 9% |
| Professor > Associate Professor | 5 | 4% |
| Other | 16 | 14% |
| Unknown | 36 | 32% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 19 | 17% |
| Pharmacology, Toxicology and Pharmaceutical Science | 14 | 13% |
| Materials Science | 11 | 10% |
| Engineering | 7 | 6% |
| Biochemistry, Genetics and Molecular Biology | 5 | 4% |
| Other | 17 | 15% |
| Unknown | 39 | 35% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 February 2017.
All research outputs
#7,363,939
of 25,394,764 outputs
Outputs from Materials Science & Engineering: C
#498
of 2,802 outputs
Outputs of similar age
#125,407
of 422,534 outputs
Outputs of similar age from Materials Science & Engineering: C
#12
of 65 outputs
Altmetric has tracked 25,394,764 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 2,802 research outputs from this source. They receive a mean Attention Score of 3.5. This one has done well, scoring higher than 80% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 422,534 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.
We're also able to compare this research output to 65 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.