Title |
RAGE-TLR Crosstalk Sustains Chronic Inflammation in Neurodegeneration
|
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Published in |
Molecular Neurobiology, February 2017
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DOI | 10.1007/s12035-017-0419-4 |
Pubmed ID | |
Authors |
Kazimierz Gąsiorowski, Barbara Brokos, Valentina Echeverria, George E. Barreto, Jerzy Leszek |
Abstract |
Chronic inflammatory reactions are consistenly present in neurodegeneration of Alzheimer type and are considered important factors that accelerate progression of the disease. Receptors of innate immunity participate in triggering and driving inflammatory reactions. For example, Toll-like receptors (TLRs) and receptor for advanced glycation end product (RAGE), major receptors of innate immunity, play a central role in perpetuation of inflammation. RAGE activation should be perceived as a primary mechanism which determines self-perpetuated chronic inflammation, and RAGE cooperation with TLRs amplifies inflammatory signaling. In this review, we highlight and discuss that RAGE-TLR crosstalk emerges as an important driving force of chronic inflammation in Alzheimer's disease. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 50% |
Japan | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Science communicators (journalists, bloggers, editors) | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 85 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 13 | 15% |
Student > Bachelor | 13 | 15% |
Researcher | 10 | 12% |
Other | 8 | 9% |
Student > Master | 7 | 8% |
Other | 10 | 12% |
Unknown | 24 | 28% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 14 | 16% |
Biochemistry, Genetics and Molecular Biology | 13 | 15% |
Neuroscience | 8 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 6 | 7% |
Medicine and Dentistry | 6 | 7% |
Other | 10 | 12% |
Unknown | 28 | 33% |