| Title |
Vimentin in cancer and its potential as a molecular target for cancer therapy
|
|---|---|
| Published in |
Cellular and Molecular Life Sciences, June 2011
|
| DOI | 10.1007/s00018-011-0735-1 |
| Pubmed ID | |
| Authors |
Arun Satelli, Shulin Li |
| Abstract |
Vimentin, a major constituent of the intermediate filament family of proteins, is ubiquitously expressed in normal mesenchymal cells and is known to maintain cellular integrity and provide resistance against stress. Vimentin is overexpressed in various epithelial cancers, including prostate cancer, gastrointestinal tumors, tumors of the central nervous system, breast cancer, malignant melanoma, and lung cancer. Vimentin's overexpression in cancer correlates well with accelerated tumor growth, invasion, and poor prognosis; however, the role of vimentin in cancer progression remains obscure. In recent years, vimentin has been recognized as a marker for epithelial-mesenchymal transition (EMT). Although EMT is associated with several tumorigenic events, vimentin's role in the underlying events mediating these processes remains unknown. By virtue of its overexpression in cancer and its association with tumor growth and metastasis, vimentin serves as an attractive potential target for cancer therapy; however, more research would be crucial to evaluate its specific role in cancer. Our recent discovery of a vimentin-binding mini-peptide has generated further impetus for vimentin-targeted tumor-specific therapy. Furthermore, research directed toward elucidating the role of vimentin in various signaling pathways would reveal new approaches for the development of therapeutic agents. This review summarizes the expression and functions of vimentin in various types of cancer and suggests some directions toward future cancer therapy utilizing vimentin as a potential molecular target. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Science communicators (journalists, bloggers, editors) | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 828 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | <1% |
| Poland | 2 | <1% |
| Switzerland | 1 | <1% |
| Malaysia | 1 | <1% |
| Finland | 1 | <1% |
| United Kingdom | 1 | <1% |
| Canada | 1 | <1% |
| Germany | 1 | <1% |
| Spain | 1 | <1% |
| Other | 3 | <1% |
| Unknown | 812 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 156 | 19% |
| Student > Master | 125 | 15% |
| Student > Bachelor | 111 | 13% |
| Researcher | 88 | 11% |
| Student > Doctoral Student | 35 | 4% |
| Other | 98 | 12% |
| Unknown | 215 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 179 | 22% |
| Agricultural and Biological Sciences | 162 | 20% |
| Medicine and Dentistry | 106 | 13% |
| Engineering | 30 | 4% |
| Pharmacology, Toxicology and Pharmaceutical Science | 25 | 3% |
| Other | 86 | 10% |
| Unknown | 240 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 25. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 December 2023.
All research outputs
#1,431,147
of 24,127,260 outputs
Outputs from Cellular and Molecular Life Sciences
#130
of 5,568 outputs
Outputs of similar age
#5,816
of 114,570 outputs
Outputs of similar age from Cellular and Molecular Life Sciences
#2
of 37 outputs
Altmetric has tracked 24,127,260 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,568 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 114,570 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 37 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.