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Attention Score in Context
| Title |
High-resolution structure of TBP with TAF1 reveals anchoring patterns in transcriptional regulation
|
|---|---|
| Published in |
Nature Structural & Molecular Biology, July 2013
|
| DOI | 10.1038/nsmb.2611 |
| Pubmed ID | |
| Authors |
Madhanagopal Anandapadamanaban, Cecilia Andresen, Sara Helander, Yoshifumi Ohyama, Marina I Siponen, Patrik Lundström, Tetsuro Kokubo, Mitsuhiko Ikura, Martin Moche, Maria Sunnerhagen |
| Abstract |
The general transcription factor TFIID provides a regulatory platform for transcription initiation. Here we present the crystal structure (1.97 Å) and NMR analysis of yeast TAF1 N-terminal domains TAND1 and TAND2 bound to yeast TBP, together with mutational data. We find that yeast TAF1-TAND1, which in itself acts as a transcriptional activator, binds TBP's concave DNA-binding surface by presenting similar anchor residues to TBP as does Mot1 but from a distinct structural scaffold. Furthermore, we show how TAF1-TAND2 uses an aromatic and acidic anchoring pattern to bind a conserved TBP surface groove traversing the basic helix region, and we find highly similar TBP-binding motifs also presented by the structurally distinct TFIIA, Mot1 and Brf1 proteins. Our identification of these anchoring patterns, which can be easily disrupted or enhanced, provides insight into the competitive multiprotein TBP interplay critical to transcriptional regulation. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 82 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 1% |
| Germany | 1 | 1% |
| Australia | 1 | 1% |
| Unknown | 79 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 16 | 20% |
| Researcher | 13 | 16% |
| Student > Master | 13 | 16% |
| Student > Bachelor | 7 | 9% |
| Student > Doctoral Student | 7 | 9% |
| Other | 15 | 18% |
| Unknown | 11 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 39 | 48% |
| Biochemistry, Genetics and Molecular Biology | 27 | 33% |
| Chemistry | 2 | 2% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 1% |
| Chemical Engineering | 1 | 1% |
| Other | 2 | 2% |
| Unknown | 10 | 12% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 August 2013.
All research outputs
#20,656,820
of 25,374,647 outputs
Outputs from Nature Structural & Molecular Biology
#3,943
of 4,186 outputs
Outputs of similar age
#157,324
of 206,822 outputs
Outputs of similar age from Nature Structural & Molecular Biology
#39
of 45 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,186 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.5. This one is in the 2nd percentile – i.e., 2% of its peers scored the same or lower than it.
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