| Title |
Perturbations of the anti-ageing hormone Klotho in patients with type 1 diabetes and microalbuminuria
|
|---|---|
| Published in |
Diabetologia, February 2017
|
| DOI | 10.1007/s00125-017-4219-1 |
| Pubmed ID | |
| Authors |
Giuseppe Maltese, Nikolaos Fountoulakis, Richard C. Siow, Luigi Gnudi, Janaka Karalliedde |
| Abstract |
Patients with type 1 diabetes and microalbuminuria are at high risk of cardiovascular disease (CVD) and end-stage renal disease. Soluble Klotho is an anti-ageing circulating hormone involved in phosphate metabolism and vascular homeostasis through protective effects on the endothelium and antioxidant actions. The role of soluble Klotho in patients with type 1 diabetes and microalbuminuria is unknown. In a cross-sectional single-centre study we evaluated the levels of circulating serum soluble Klotho in 33 participants with type 1 diabetes and a history of microalbuminuria (receiving renin-angiotensin system [RAS] inhibitors) and 45 participants with type 1 diabetes without a history of microalbuminuria (not receiving RAS or other antihypertensive drugs). All participants had an eGFR >45 ml/min, duration of diabetes >20 years and no history of CVD. Serum soluble Klotho levels were measured by a validated immunoassay. Participants with microalbuminuria had significantly lower levels of serum Klotho compared with those without microalbuminuria (median [interquartile range], 659.3 [525.3, 827.6] vs 787.7 [629.5, 1007]; p = 0.023). This difference persisted after adjustment for variables including age and eGFR. In a subgroup of 30 individuals with and without microalbuminuria, other markers of phosphate balance were not significantly different. In individuals with type 1 diabetes, microalbuminuria is associated with soluble Klotho deficiency. Further studies are required to determine whether soluble Klotho is causally related to the development of cardio-renal disease in type 1 diabetes. |
X Demographics
The data shown below were collected from the profiles of 19 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 5 | 26% |
| France | 3 | 16% |
| United States | 1 | 5% |
| Switzerland | 1 | 5% |
| South Africa | 1 | 5% |
| Canada | 1 | 5% |
| Ecuador | 1 | 5% |
| Unknown | 6 | 32% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 13 | 68% |
| Scientists | 3 | 16% |
| Practitioners (doctors, other healthcare professionals) | 3 | 16% |
Mendeley readers
The data shown below were compiled from readership statistics for 37 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 37 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 4 | 11% |
| Student > Master | 4 | 11% |
| Student > Bachelor | 4 | 11% |
| Other | 3 | 8% |
| Student > Doctoral Student | 2 | 5% |
| Other | 8 | 22% |
| Unknown | 12 | 32% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 10 | 27% |
| Agricultural and Biological Sciences | 4 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 5% |
| Biochemistry, Genetics and Molecular Biology | 1 | 3% |
| Nursing and Health Professions | 1 | 3% |
| Other | 5 | 14% |
| Unknown | 14 | 38% |
Attention Score in Context
This research output has an Altmetric Attention Score of 176. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 November 2021.
All research outputs
#230,615
of 25,547,904 outputs
Outputs from Diabetologia
#136
of 5,361 outputs
Outputs of similar age
#5,205
of 432,897 outputs
Outputs of similar age from Diabetologia
#5
of 64 outputs
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