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X Demographics
Mendeley readers
Attention Score in Context
| Title |
m6A-dependent maternal mRNA clearance facilitates zebrafish maternal-to-zygotic transition
|
|---|---|
| Published in |
Nature, February 2017
|
| DOI | 10.1038/nature21355 |
| Pubmed ID | |
| Authors |
Boxuan Simen Zhao, Xiao Wang, Alana V. Beadell, Zhike Lu, Hailing Shi, Adam Kuuspalu, Robert K. Ho, Chuan He |
| Abstract |
The maternal-to-zygotic transition (MZT) is one of the most profound and tightly orchestrated processes during the early life of embryos, yet factors that shape the temporal pattern of vertebrate MZT are largely unknown. Here we show that over one-third of zebrafish maternal messenger RNAs (mRNAs) can be N(6)-methyladenosine (m(6)A) modified, and the clearance of these maternal mRNAs is facilitated by an m(6)A-binding protein, Ythdf2. Removal of Ythdf2 in zebrafish embryos decelerates the decay of m(6)A-modified maternal mRNAs and impedes zygotic genome activation. These embryos fail to initiate timely MZT, undergo cell-cycle pause, and remain developmentally delayed throughout larval life. Our study reveals m(6)A-dependent RNA decay as a previously unidentified maternally driven mechanism that regulates maternal mRNA clearance during zebrafish MZT, highlighting the critical role of m(6)A mRNA methylation in transcriptome switching and animal development. |
X Demographics
The data shown below were collected from the profiles of 52 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 15 | 29% |
| India | 2 | 4% |
| United Kingdom | 2 | 4% |
| Germany | 1 | 2% |
| Hong Kong | 1 | 2% |
| Tanzania, United Republic of | 1 | 2% |
| China | 1 | 2% |
| United Arab Emirates | 1 | 2% |
| Belgium | 1 | 2% |
| Other | 4 | 8% |
| Unknown | 23 | 44% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 29 | 56% |
| Scientists | 18 | 35% |
| Science communicators (journalists, bloggers, editors) | 4 | 8% |
| Practitioners (doctors, other healthcare professionals) | 1 | 2% |
Mendeley readers
The data shown below were compiled from readership statistics for 498 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | <1% |
| South Africa | 1 | <1% |
| Italy | 1 | <1% |
| Japan | 1 | <1% |
| United Kingdom | 1 | <1% |
| Unknown | 492 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 143 | 29% |
| Researcher | 63 | 13% |
| Student > Master | 53 | 11% |
| Student > Bachelor | 50 | 10% |
| Student > Doctoral Student | 41 | 8% |
| Other | 58 | 12% |
| Unknown | 90 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 204 | 41% |
| Agricultural and Biological Sciences | 129 | 26% |
| Medicine and Dentistry | 16 | 3% |
| Chemistry | 14 | 3% |
| Neuroscience | 8 | 2% |
| Other | 27 | 5% |
| Unknown | 100 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 63. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 December 2022.
All research outputs
#660,103
of 25,040,629 outputs
Outputs from Nature
#26,063
of 96,617 outputs
Outputs of similar age
#15,108
of 437,505 outputs
Outputs of similar age from Nature
#520
of 903 outputs
Altmetric has tracked 25,040,629 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 96,617 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 102.2. This one has gotten more attention than average, scoring higher than 73% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 437,505 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 903 others from the same source and published within six weeks on either side of this one. This one is in the 42nd percentile – i.e., 42% of its contemporaries scored the same or lower than it.