| Title |
Severe Constrictive Pericarditis After Parvovirus B19 and Human Herpes Virus 6 Infection in a 9-Year-Old Girl
|
|---|---|
| Published in |
Pediatric Cardiology, July 2013
|
| DOI | 10.1007/s00246-013-0755-8 |
| Pubmed ID | |
| Authors |
David Backhoff, Michael Steinmetz, Wolfgang Ruschewski, Barbara Stastny, Reinhard Kandolf, Ulrich Krause |
| Abstract |
We report on a 9-year-old girl who developed signs of congestive heart failure with significant ascites due to constrictive pericarditis. Cardiac catheterization was performed to establish the diagnosis and to rule out restrictive cardiomyopathy. Endomyocardial biopsies were positive for activated macrophages and small-vessel disease, but no viral genomes were detected. Open pericardectomy was performed and histopathologic examination of the resected thickened pericardium showed extensive fibrosis and hyaline degeneration. A combined infection with parvovirus B19 (PVB19) and human herpes virus 6 (HHV6; subtype B) was proven within the resected pericardium. We suggest that local HHV6-induced immunosuppression enhanced the PVB19 infection, thus resulting in chronic infection and leading to constrictive pericarditis. |
Mendeley readers
The data shown below were compiled from readership statistics for 8 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 8 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 3 | 38% |
| Librarian | 1 | 13% |
| Other | 1 | 13% |
| Unknown | 3 | 38% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 4 | 50% |
| Unknown | 4 | 50% |