| Title |
Serum and tissue trace elements in patients with breast cancer in Taiwan
|
|---|---|
| Published in |
Biological Trace Element Research, January 2002
|
| DOI | 10.1385/bter:89:1:1 |
| Pubmed ID | |
| Authors |
Hsien Wen Kuo, Su Fan Chen, Chin Ching Wu, Dar Ren Chen, Jau Hung Lee |
| Abstract |
The objective of this study was to compare levels of four elements (zinc, copper, selenium, and iron) in the serum and tissue of 68 breast tumor patients (benign and malignant), from a teaching hospital in central Taiwan. Samples of normal tissue (5 cm away from tumor) were also taken from patients with malignant tumors. Only serum was taken from the 25 healthy persons in the control group. Results showed that Zn, Cu, Se, Fe, Cu/Zn, Cu/Se, and Cu/Fe were present in different amounts in the serum of each of the three groups. Zn and Se levels were lower in the serum of the two tumor groups compared to the control group. In tissue samples, Zn, Cu, Se, and Fe concentrations were different in each of the three groups. The malignant tissue had the highest levels of all four elements. In advanced-stage malignant tumors, levels of Cu and the ratios of Cu/Fe and Cu/Zn (in both serum and tissue) were highest. The ratios of serum Cu/Zn, Cu/Fe, and Cu/Se were also higher in malignant patients. The cutoff value of serum Cu/Zn was 1.2 (sensitivity and specificity were both 100%). The Cu/Zn ratio was highest in the advanced stages of cancer and was a better diagnostic tool for breast cancer than Cu/Se and Cu/Fe. The authors suggest that change of trace elements in serum and tissue might be useful and significant as biomarkers involving the initial plastic process. |
Mendeley readers
The data shown below were compiled from readership statistics for 93 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Austria | 1 | 1% |
| Unknown | 92 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 24 | 26% |
| Researcher | 12 | 13% |
| Student > Bachelor | 12 | 13% |
| Student > Master | 11 | 12% |
| Student > Doctoral Student | 5 | 5% |
| Other | 11 | 12% |
| Unknown | 18 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 17 | 18% |
| Medicine and Dentistry | 13 | 14% |
| Biochemistry, Genetics and Molecular Biology | 10 | 11% |
| Agricultural and Biological Sciences | 10 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 4% |
| Other | 13 | 14% |
| Unknown | 26 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 June 2021.
All research outputs
#20,656,161
of 25,373,627 outputs
Outputs from Biological Trace Element Research
#1,611
of 2,336 outputs
Outputs of similar age
#126,179
of 130,776 outputs
Outputs of similar age from Biological Trace Element Research
#19
of 21 outputs
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