Title |
Relative Carnitine Deficiency in Autism
|
---|---|
Published in |
Journal of Autism and Developmental Disorders, December 2004
|
DOI | 10.1007/s10803-004-5283-1 |
Pubmed ID | |
Authors |
Pauline A. Filipek, Jenifer Juranek, Minh T. Nguyen, Christa Cummings, J. Jay Gargus |
Abstract |
A random retrospective chart review was conducted to document serum carnitine levels on 100 children with autism. Concurrently drawn serum pyruvate, lactate, ammonia, and alanine levels were also available in many of these children. Values of free and total carnitine (p < 0.001), and pyruvate (p = 0.006) were significantly reduced while ammonia and alanine levels were considerably elevated (p < 0.001) in our autistic subjects. The relative carnitine deficiency in these patients, accompanied by slight elevations in lactate and significant elevations in alanine and ammonia levels, is suggestive of mild mitochondrial dysfunction. It is hypothesized that a mitochondrial defect may be the origin of the carnitine deficiency in these autistic children. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 25% |
Italy | 1 | 25% |
Canada | 1 | 25% |
Unknown | 1 | 25% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 75% |
Practitioners (doctors, other healthcare professionals) | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | <1% |
Australia | 1 | <1% |
Unknown | 106 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 18 | 17% |
Researcher | 13 | 12% |
Student > Ph. D. Student | 13 | 12% |
Student > Bachelor | 13 | 12% |
Other | 10 | 9% |
Other | 17 | 16% |
Unknown | 24 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 20 | 19% |
Agricultural and Biological Sciences | 16 | 15% |
Biochemistry, Genetics and Molecular Biology | 8 | 7% |
Psychology | 6 | 6% |
Neuroscience | 5 | 5% |
Other | 23 | 21% |
Unknown | 30 | 28% |