| Title |
Contrast-associated acute kidney injury in the critically ill: systematic review and Bayesian meta-analysis
|
|---|---|
| Published in |
Intensive Care Medicine, February 2017
|
| DOI | 10.1007/s00134-017-4700-9 |
| Pubmed ID | |
| Authors |
Stephan Ehrmann, Andrew Quartin, Brian P Hobbs, Vincent Robert-Edan, Cynthia Cely, Cynthia Bell, Genevieve Lyons, Tai Pham, Roland Schein, Yimin Geng, Karim Lakhal, Chaan S. Ng |
| Abstract |
Critically ill patients, among whom acute kidney injury is common, are often considered particularly vulnerable to iodinated contrast medium nephrotoxicity. However, the attributable incidence remains uncertain given the paucity of observational studies including a control group. This study assessed acute kidney injury incidence attributable to iodinated contrast media in critically ill patients based on new data accounting for sample and effect size and including a control group. Systematic review of studies measuring incidence of acute kidney injury in critically ill patients following contrast medium exposure compared to matched unexposed patients. Patient-level meta-analysis implementing a Bayesian nested mixed effects multiple logistic regression model. Ten studies were identified; only four took into account the baseline acute kidney injury risk, three by patient matching (560 patients). Objective meta-analysis of these three studies (vague and impartial a priori hypothesis concerning attributable acute kidney injury risk) did not find that iodinated contrast media increased the incidence of acute kidney injury (odds ratio 0.95, 95% highest posterior density interval 0.45-1.62). Bayesian analysis demonstrated that, to conclude in favor of a statistically significant incidence of acute kidney injury attributable to contrast media despite this observed lack of association, one's a priori belief would have to be very strongly biased, assigning to previous uncontrolled reports 3-12 times the weight of evidence strength provided by the matched studies including a control group. Meta-analysis of matched cohort studies of iodinated contrast medium exposure does not support a significant incidence of acute kidney injury attributable to iodinated contrast media in critically ill patients. |
X Demographics
The data shown below were collected from the profiles of 30 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 5 | 17% |
| United Kingdom | 5 | 17% |
| Canada | 2 | 7% |
| Netherlands | 2 | 7% |
| Colombia | 1 | 3% |
| United Arab Emirates | 1 | 3% |
| Argentina | 1 | 3% |
| Sweden | 1 | 3% |
| Switzerland | 1 | 3% |
| Other | 4 | 13% |
| Unknown | 7 | 23% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 20 | 67% |
| Scientists | 5 | 17% |
| Practitioners (doctors, other healthcare professionals) | 5 | 17% |
Mendeley readers
The data shown below were compiled from readership statistics for 144 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 144 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Other | 21 | 15% |
| Researcher | 14 | 10% |
| Student > Ph. D. Student | 13 | 9% |
| Student > Master | 13 | 9% |
| Student > Doctoral Student | 11 | 8% |
| Other | 37 | 26% |
| Unknown | 35 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 87 | 60% |
| Nursing and Health Professions | 9 | 6% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 2% |
| Engineering | 2 | 1% |
| Psychology | 2 | 1% |
| Other | 5 | 3% |
| Unknown | 36 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 24. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 November 2023.
All research outputs
#1,554,495
of 25,353,525 outputs
Outputs from Intensive Care Medicine
#1,341
of 5,394 outputs
Outputs of similar age
#33,547
of 440,767 outputs
Outputs of similar age from Intensive Care Medicine
#34
of 124 outputs
Altmetric has tracked 25,353,525 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,394 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 29.7. This one has done well, scoring higher than 75% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 440,767 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 124 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.