| Title |
Inhibition of astroglial NF-kappaB enhances oligodendrogenesis following spinal cord injury
|
|---|---|
| Published in |
Journal of Neuroinflammation, July 2013
|
| DOI | 10.1186/1742-2094-10-92 |
| Pubmed ID | |
| Authors |
Valerie Bracchi-Ricard, Kate L Lambertsen, Jerome Ricard, Lubov Nathanson, Shaffiat Karmally, Joshua Johnstone, Ditte G Ellman, Beata Frydel, Dana M McTigue, John R Bethea |
| Abstract |
Astrocytes are taking the center stage in neurotrauma and neurological diseases as they appear to play a dominant role in the inflammatory processes associated with these conditions. Previously, we reported that inhibiting NF-κB activation in astrocytes, using a transgenic mouse model (GFAP-IκBα-dn mice), results in improved functional recovery, increased white matter preservation and axonal sparing following spinal cord injury (SCI). In the present study, we sought to determine whether this improvement, due to inhibiting NF-κB activation in astrocytes, could be the result of enhanced oligodendrogenesis in our transgenic mice. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 62 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 2% |
| Ireland | 1 | 2% |
| Unknown | 60 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 15 | 24% |
| Researcher | 12 | 19% |
| Student > Master | 8 | 13% |
| Student > Bachelor | 7 | 11% |
| Student > Postgraduate | 7 | 11% |
| Other | 5 | 8% |
| Unknown | 8 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 17 | 27% |
| Medicine and Dentistry | 12 | 19% |
| Neuroscience | 12 | 19% |
| Biochemistry, Genetics and Molecular Biology | 6 | 10% |
| Psychology | 1 | 2% |
| Other | 3 | 5% |
| Unknown | 11 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 July 2013.
All research outputs
#18,341,711
of 22,714,025 outputs
Outputs from Journal of Neuroinflammation
#2,056
of 2,613 outputs
Outputs of similar age
#148,248
of 197,837 outputs
Outputs of similar age from Journal of Neuroinflammation
#22
of 32 outputs
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