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Mendeley readers
Attention Score in Context
| Title |
Cutting Edge: ABIN-1 Protects against Psoriasis by Restricting MyD88 Signals in Dendritic Cells
|
|---|---|
| Published in |
The Journal of Immunology, July 2013
|
| DOI | 10.4049/jimmunol.1203335 |
| Pubmed ID | |
| Authors |
Joseph A. Callahan, Gianna E. Hammer, Alexander Agelides, Bao H. Duong, Shigeru Oshima, Jeffrey North, Rommel Advincula, Nataliya Shifrin, Hong-An Truong, Jonathan Paw, Julio Barrera, Anthony DeFranco, Michael D. Rosenblum, Barbara A. Malynn, Averil Ma |
| Abstract |
Psoriasis is a chronic, inflammatory skin disease caused by a combination of environmental and genetic factors. The Tnip1 gene encodes A20 binding and inhibitor of NF-κB-1 (ABIN-1) protein and is strongly associated with susceptibility to psoriasis in humans. ABIN-1, a widely expressed ubiquitin-binding protein, restricts TNF- and TLR-induced signals. In this study, we report that mice lacking ABIN-1 specifically in dendritic cells (DCs), ABIN-1(fl) CD11c-Cre mice, exhibit perturbed immune homeostasis. ABIN-1-deficient DCs display exaggerated NF-κB and MAPK signaling and produce more IL-23 than do normal cells in response to TLR ligands. Challenge of ABIN-1(fl) CD11c-Cre mice with topical TLR7 ligand leads to greater numbers of Th17 and TCRγδ T cells and exacerbated development of psoriaform lesions. These phenotypes are reversed by DC-specific deletion of the TLR adaptor MyD88. These studies link ABIN-1 with IL-23 and IL-17, and they provide cellular and molecular mechanisms by which ABIN-1 regulates susceptibility to psoriasis. |
Mendeley readers
The data shown below were compiled from readership statistics for 54 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 2% |
| United States | 1 | 2% |
| China | 1 | 2% |
| Unknown | 51 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 14 | 26% |
| Student > Ph. D. Student | 14 | 26% |
| Student > Bachelor | 6 | 11% |
| Other | 5 | 9% |
| Student > Doctoral Student | 3 | 6% |
| Other | 5 | 9% |
| Unknown | 7 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 18 | 33% |
| Medicine and Dentistry | 10 | 19% |
| Immunology and Microbiology | 9 | 17% |
| Biochemistry, Genetics and Molecular Biology | 7 | 13% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
| Other | 2 | 4% |
| Unknown | 7 | 13% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 May 2014.
All research outputs
#14,807,732
of 22,800,560 outputs
Outputs from The Journal of Immunology
#15,639
of 19,714 outputs
Outputs of similar age
#115,974
of 194,639 outputs
Outputs of similar age from The Journal of Immunology
#184
of 264 outputs
Altmetric has tracked 22,800,560 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 19,714 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.9. This one is in the 18th percentile – i.e., 18% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 194,639 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 264 others from the same source and published within six weeks on either side of this one. This one is in the 29th percentile – i.e., 29% of its contemporaries scored the same or lower than it.