| Title |
Cooked Common Beans (Phaseolus vulgaris) Protect Against β-cell Damage in Streptozotocin-Induced Diabetic Rats
|
|---|---|
| Published in |
Plant Foods for Human Nutrition, April 2013
|
| DOI | 10.1007/s11130-013-0353-1 |
| Pubmed ID | |
| Authors |
Diego Hernández-Saavedra, Magdalena Mendoza-Sánchez, Hebert L. Hernández-Montiel, Horacio S. Guzmán-Maldonado, Guadalupe F. Loarca-Piña, Luis M. Salgado, Rosalía Reynoso-Camacho |
| Abstract |
Diabetes is a disease characterized by a hyperglycemic stage that leads to a chronic inflammatory state. We evaluated the in vivo effect of a diet supplemented with 25 % cooked black bean cultivar Negro 8025 (N8025) flour in streptozotocin-induced diabetic rats. The effect was assessed before (preventive-treatment) and after (treatment) the onset of diabetes. There is a significant decrease of total phenolic, tannins and anthocyanins content after cooking, and the concentration of most of the single phenols analyzed are only slightly decreased. The treatment group showed a significant reduction of glucose (22.8 %), triglycerides (21.9 %), total cholesterol (29.9 %) and LDL (56.1 %) that correlates with a protection of pancreatic ß-cells. The diet with N8025 flour before the induction of diabetes did not exert a protective effect (glucose levels are similar to the diabetic control) but they have low levels of total cholesterol (47.5 %) and LDL (56.1 %). The preventive-treatment group did not inhibit the increase of TNF-α and IL-1β, whereas the treatment group did, compared to the diabetic control. Therefore, N8025 bean supplementation can be recommended to control diabetes. |
Mendeley readers
The data shown below were compiled from readership statistics for 51 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 51 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 7 | 14% |
| Student > Master | 7 | 14% |
| Student > Postgraduate | 6 | 12% |
| Professor | 5 | 10% |
| Researcher | 5 | 10% |
| Other | 7 | 14% |
| Unknown | 14 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 14 | 27% |
| Biochemistry, Genetics and Molecular Biology | 5 | 10% |
| Medicine and Dentistry | 4 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 6% |
| Business, Management and Accounting | 1 | 2% |
| Other | 3 | 6% |
| Unknown | 21 | 41% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 July 2013.
All research outputs
#20,196,270
of 22,714,025 outputs
Outputs from Plant Foods for Human Nutrition
#594
of 701 outputs
Outputs of similar age
#172,227
of 197,462 outputs
Outputs of similar age from Plant Foods for Human Nutrition
#11
of 11 outputs
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