| Title |
Adherence to Mediterranean diet is associated with methylation changes in inflammation-related genes in peripheral blood cells
|
|---|---|
| Published in |
Journal of Physiology and Biochemistry, February 2017
|
| DOI | 10.1007/s13105-017-0552-6 |
| Pubmed ID | |
| Authors |
A. Arpón, J. I. Riezu-Boj, F. I. Milagro, A Marti, C. Razquin, M. A. Martínez-González, D. Corella, R. Estruch, R. Casas, M. Fitó, E. Ros, J. Salas-Salvadó, J. A. Martínez |
| Abstract |
Epigenetic processes, including DNA methylation, might be modulated by environmental factors such as the diet, which in turn have been associated with the onset of several diseases such as obesity or cardiovascular events. Meanwhile, Mediterranean diet (MedDiet) has demonstrated favourable effects on cardiovascular risk, blood pressure, inflammation and other complications related to excessive adiposity. Some of these effects could be mediated by epigenetic modifications. Therefore, the objective of this study was to investigate whether the adherence to MedDiet is associated with changes in the methylation status from peripheral blood cells. A subset of 36 individuals was selected within the Prevención con Dieta Mediterránea (PREDIMED)-Navarra study, a randomised, controlled, parallel trial with three groups of intervention in high cardiovascular risk volunteers, two with a MedDiet and one low-fat control group. Changes in methylation between baseline and 5 years were studied. DNA methylation arrays were analysed by several robust statistical tests and functional classifications. Eight genes related to inflammation and immunocompetence (EEF2, COL18A1, IL4I1, LEPR, PLAGL1, IFRD1, MAPKAPK2, PPARGC1B) were finally selected as changes in their methylation levels correlated with adherence to MedDiet and because they presented sensitivity related to a high variability in methylation changes. Additionally, EEF2 methylation levels positively correlated with concentrations of TNF-α and CRP. This report is apparently the first showing that adherence to MedDiet is associated with the methylation of the reported genes related to inflammation with a potential regulatory impact. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 33% |
| United Kingdom | 1 | 33% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Science communicators (journalists, bloggers, editors) | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 227 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | <1% |
| Unknown | 226 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 37 | 16% |
| Student > Bachelor | 30 | 13% |
| Student > Ph. D. Student | 23 | 10% |
| Researcher | 22 | 10% |
| Student > Postgraduate | 14 | 6% |
| Other | 40 | 18% |
| Unknown | 61 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 40 | 18% |
| Biochemistry, Genetics and Molecular Biology | 36 | 16% |
| Nursing and Health Professions | 33 | 15% |
| Agricultural and Biological Sciences | 16 | 7% |
| Neuroscience | 5 | 2% |
| Other | 21 | 9% |
| Unknown | 76 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 29. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 November 2023.
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#1,380,742
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Outputs from Journal of Physiology and Biochemistry
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Outputs of similar age from Journal of Physiology and Biochemistry
#1
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