Title |
Reduced thrombin formation and excessive fibrinolysis are associated with bleeding complications in patients with dengue fever: a case–control study comparing dengue fever patients with and without bleeding manifestations
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Published in |
BMC Infectious Diseases, July 2013
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DOI | 10.1186/1471-2334-13-350 |
Pubmed ID | |
Authors |
Fernanda A Orsi, Rodrigo N Angerami, Bruna M Mazetto, Susan KP Quaino, Fernanda Santiago-Bassora, Vagner Castro, Erich V de Paula, Joyce M Annichino-Bizzacchi |
Abstract |
Dengue cases have been classified according to disease severity into dengue fever (DF) and dengue hemorrhagic fever (DHF). Although DF is considered a non-severe manifestation of dengue, it has been recently demonstrated that DF represents a heterogeneous group of patients with varied clinical complications and grades of severity. Particularly, bleeding complications, commonly associated to DHF, can be detected in half of the patients with DF. Although a frequent complication, the causes of bleedings in DF have not been fully addressed. Thus, the aim of this study was to perform a comprehensive evaluation of possible pathophysiological mechanisms that could contribute to the bleeding tendency observed in patients with DF. |
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Unknown | 1 | 100% |
Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 74 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Postgraduate | 11 | 15% |
Student > Ph. D. Student | 10 | 14% |
Student > Master | 10 | 14% |
Student > Bachelor | 9 | 12% |
Researcher | 8 | 11% |
Other | 15 | 20% |
Unknown | 11 | 15% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 5 | 7% |
Immunology and Microbiology | 5 | 7% |
Biochemistry, Genetics and Molecular Biology | 4 | 5% |
Social Sciences | 3 | 4% |
Other | 5 | 7% |
Unknown | 14 | 19% |