Title |
Advancement of human leukocyte antigen-partially matched related hematopoietic stem cell transplantation
|
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Published in |
Frontiers of Medicine, July 2013
|
DOI | 10.1007/s11684-013-0279-x |
Pubmed ID | |
Authors |
Xiaodong Mo, Xiaojun Huang |
Abstract |
Allogeneic hematopoietic stem cell transplantation (HSCT) is one of the most effective options for hematological malignancies, and human leukocyte antigen-partially matched related donors (PMRDs) are a valuable option for HSCT. Several protocols (with or without ex vivo T-cell depletion (TCD)) have been established worldwide. TCD including CD34(+) positive selection and CD3/CD19 depletion has successfully overcome the human leukocyte antigen disparity. However, TCD is associated with prolonged immune deficiencies, increased risks of infectious complications, and high transplantation-related mortality. PMRD HSCTwithout ex vivo TCD is well developed, and numerous patients have benefitted from it. Here, we review the literature on PMRD HSCT. |
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Geographical breakdown
Country | Count | As % |
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United States | 2 | 33% |
India | 1 | 17% |
Comoros | 1 | 17% |
Unknown | 2 | 33% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 50% |
Scientists | 2 | 33% |
Science communicators (journalists, bloggers, editors) | 1 | 17% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 1 | 20% |
Other | 1 | 20% |
Student > Master | 1 | 20% |
Unknown | 2 | 40% |
Readers by discipline | Count | As % |
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Environmental Science | 1 | 20% |
Computer Science | 1 | 20% |
Engineering | 1 | 20% |
Unknown | 2 | 40% |