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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Human γδ T cells are quickly reconstituted after stem-cell transplantation and show adaptive clonal expansion in response to viral infection
|
|---|---|
| Published in |
Nature Immunology, February 2017
|
| DOI | 10.1038/ni.3686 |
| Pubmed ID | |
| Authors |
Sarina Ravens, Christian Schultze-Florey, Solaiman Raha, Inga Sandrock, Melanie Drenker, Linda Oberdörfer, Annika Reinhardt, Inga Ravens, Maleen Beck, Robert Geffers, Constantin von Kaisenberg, Michael Heuser, Felicitas Thol, Arnold Ganser, Reinhold Förster, Christian Koenecke, Immo Prinz |
| Abstract |
To investigate how the human γδ T cell pool is shaped during ontogeny and how it is regenerated after transplantation of hematopoietic stem cells (HSCs), we applied an RNA-based next-generation sequencing approach to monitor the dynamics of the repertoires of γδ T cell antigen receptors (TCRs) before and after transplantation in a prospective cohort study. We found that repertoires of rearranged genes encoding γδ TCRs (TRG and TRD) in the peripheral blood of healthy adults were stable over time. Although a large fraction of human TRG repertoires consisted of public sequences, the TRD repertoires were private. In patients undergoing HSC transplantation, γδ T cells were quickly reconstituted; however, they had profoundly altered TCR repertoires. Notably, the clonal proliferation of individual virus-reactive γδ TCR sequences in patients with reactivation of cytomegalovirus revealed strong evidence for adaptive anti-viral γδ T cell immune responses. |
X Demographics
The data shown below were collected from the profiles of 30 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 17% |
| United Kingdom | 3 | 10% |
| El Salvador | 1 | 3% |
| Russia | 1 | 3% |
| France | 1 | 3% |
| Indonesia | 1 | 3% |
| Canada | 1 | 3% |
| Australia | 1 | 3% |
| Belgium | 1 | 3% |
| Other | 1 | 3% |
| Unknown | 14 | 47% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 18 | 60% |
| Scientists | 8 | 27% |
| Practitioners (doctors, other healthcare professionals) | 2 | 7% |
| Science communicators (journalists, bloggers, editors) | 2 | 7% |
Mendeley readers
The data shown below were compiled from readership statistics for 248 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | <1% |
| Germany | 1 | <1% |
| Unknown | 245 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 52 | 21% |
| Researcher | 47 | 19% |
| Student > Master | 28 | 11% |
| Student > Bachelor | 21 | 8% |
| Student > Doctoral Student | 15 | 6% |
| Other | 36 | 15% |
| Unknown | 49 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 72 | 29% |
| Medicine and Dentistry | 39 | 16% |
| Biochemistry, Genetics and Molecular Biology | 34 | 14% |
| Agricultural and Biological Sciences | 32 | 13% |
| Social Sciences | 2 | <1% |
| Other | 10 | 4% |
| Unknown | 59 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 42. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 June 2023.
All research outputs
#1,008,882
of 26,017,215 outputs
Outputs from Nature Immunology
#663
of 4,234 outputs
Outputs of similar age
#20,444
of 327,596 outputs
Outputs of similar age from Nature Immunology
#14
of 50 outputs
Altmetric has tracked 26,017,215 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,234 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 35.7. This one has done well, scoring higher than 84% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 327,596 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 50 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.