Title |
The recurrent PPP1CB mutation p.Pro49Arg in an additional Noonan‐like syndrome individual: Broadening the clinical phenotype
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Published in |
American Journal of Medical Genetics. Part A, February 2017
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DOI | 10.1002/ajmg.a.38070 |
Pubmed ID | |
Authors |
Débora Bertola, Guilherme Yamamoto, Michelle Buscarilli, Alexander Jorge, Maria Rita Passos‐Bueno, Chong Kim |
Abstract |
We report on a 12-year-old Brazilian boy with the p.Pro49Arg mutation in PPP1CB, a novel gene associated with RASopathies. This is the fifth individual described, and the fourth presenting the same variant, suggesting a mutational hotspot. Phenotypically, he also showed the same hair pattern-sparse, thin, and with slow growing-, similar to the typical ectodermal finding observed in Noonan syndrome-like disorder with loose anagen hair. Additionally, he presented craniosynostosis, a rare clinical finding in RASopathies. This report gives further support that this novel RASopathy-PPP1CB-related Noonan syndrome with loose anagen hair-shares great similarity to Noonan syndrome-like disorder with loose anagen hair, and expands the phenotypic spectrum by adding the cranial vault abnormality. © 2017 Wiley Periodicals, Inc. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Saudi Arabia | 1 | 50% |
Italy | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 23 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 3 | 13% |
Student > Bachelor | 2 | 9% |
Other | 2 | 9% |
Professor | 2 | 9% |
Student > Ph. D. Student | 2 | 9% |
Other | 4 | 17% |
Unknown | 8 | 35% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 5 | 22% |
Biochemistry, Genetics and Molecular Biology | 3 | 13% |
Agricultural and Biological Sciences | 2 | 9% |
Nursing and Health Professions | 1 | 4% |
Linguistics | 1 | 4% |
Other | 1 | 4% |
Unknown | 10 | 43% |