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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Toward Drugs for Protease-Activated Receptor 2 (PAR2)
|
|---|---|
| Published in |
Journal of Medicinal Chemistry, July 2013
|
| DOI | 10.1021/jm400638v |
| Pubmed ID | |
| Authors |
Mei-Kwan Yau, Ligong Liu, David P. Fairlie |
| Abstract |
PAR2 has a distinctive functional phenotype among an unusual group of GPCRs called protease activated receptors, which self-activate after cleavage of their N-termini by mainly serine proteases. PAR2 is the most highly expressed PAR on certain immune cells, and it is activated by multiple proteases (but not thrombin) in inflammation. PAR2 is expressed on many types of primary human cells and cancer cells. PAR2 knockout mice and PAR2 agonists and antagonists have implicated PAR2 as a promising target in inflammatory conditions; respiratory, gastrointestinal, metabolic, cardiovascular, and neurological dysfunction; and cancers. This article summarizes salient features of PAR2 structure, activation, and function; opportunities for disease intervention via PAR2; pharmacological properties of published or patented PAR2 modulators (small molecule agonists and antagonists, pepducins, antibodies); and some personal perspectives on limitations of assessing their properties and on promising new directions for PAR2 modulation. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 102 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | <1% |
| Unknown | 101 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 21 | 21% |
| Student > Ph. D. Student | 18 | 18% |
| Student > Master | 14 | 14% |
| Student > Bachelor | 7 | 7% |
| Student > Doctoral Student | 6 | 6% |
| Other | 13 | 13% |
| Unknown | 23 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 17 | 17% |
| Chemistry | 17 | 17% |
| Agricultural and Biological Sciences | 17 | 17% |
| Medicine and Dentistry | 14 | 14% |
| Immunology and Microbiology | 3 | 3% |
| Other | 11 | 11% |
| Unknown | 23 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 April 2024.
All research outputs
#5,442,776
of 25,738,558 outputs
Outputs from Journal of Medicinal Chemistry
#7,414
of 23,284 outputs
Outputs of similar age
#43,757
of 210,974 outputs
Outputs of similar age from Journal of Medicinal Chemistry
#35
of 135 outputs
Altmetric has tracked 25,738,558 research outputs across all sources so far. Compared to these this one has done well and is in the 78th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 23,284 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.0. This one has gotten more attention than average, scoring higher than 67% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 210,974 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 79% of its contemporaries.
We're also able to compare this research output to 135 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.