| Title |
Amyloid-beta transporter expression at the blood-CSF barrier is age-dependent
|
|---|---|
| Published in |
Fluids and Barriers of the CNS, July 2011
|
| DOI | 10.1186/2045-8118-8-21 |
| Pubmed ID | |
| Authors |
Crissey L Pascale, Miles C Miller, Catherine Chiu, Matthew Boylan, Ilias N Caralopoulos, Liliana Gonzalez, Conrad E Johanson, Gerald D Silverberg |
| Abstract |
Age is the major risk factor for many neurodegenerative diseases, including Alzheimer's disease (AD). There is an accumulation of amyloid-beta peptides (Aβ) in both the AD brain and the normal aging brain. Clearance of Aβ from the brain occurs via active transport at the blood-brain barrier (BBB) and blood-cerebrospinal fluid barrier (BCSFB). With increasing age, the expression of the Aβ efflux transporters is decreased and the Aβ influx transporter expression is increased at the BBB, adding to the amyloid burden in the brain. Expression of the Aβ transporters at the choroid plexus (CP) epithelium as a function of aging was the subject of this study. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 115 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Iran, Islamic Republic of | 1 | <1% |
| United States | 1 | <1% |
| France | 1 | <1% |
| Unknown | 112 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 22 | 19% |
| Researcher | 17 | 15% |
| Student > Bachelor | 17 | 15% |
| Student > Master | 13 | 11% |
| Student > Doctoral Student | 6 | 5% |
| Other | 22 | 19% |
| Unknown | 18 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 32 | 28% |
| Neuroscience | 18 | 16% |
| Medicine and Dentistry | 14 | 12% |
| Biochemistry, Genetics and Molecular Biology | 11 | 10% |
| Pharmacology, Toxicology and Pharmaceutical Science | 7 | 6% |
| Other | 14 | 12% |
| Unknown | 19 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 May 2014.
All research outputs
#2,575,879
of 22,715,151 outputs
Outputs from Fluids and Barriers of the CNS
#33
of 358 outputs
Outputs of similar age
#12,975
of 116,336 outputs
Outputs of similar age from Fluids and Barriers of the CNS
#1
of 2 outputs
Altmetric has tracked 22,715,151 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 358 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.2. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 116,336 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them