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Western-style diet-induced colonic tumors and their modulation by calcium and vitamin D in C57Bl/6 mice: a preclinical model for human sporadic colon cancer

Overview of attention for article published in Carcinogenesis, September 2008
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Title
Western-style diet-induced colonic tumors and their modulation by calcium and vitamin D in C57Bl/6 mice: a preclinical model for human sporadic colon cancer
Published in
Carcinogenesis, September 2008
DOI 10.1093/carcin/bgn229
Pubmed ID
Authors

Harold L. Newmark, Kan Yang, Naoto Kurihara, Kunhua Fan, Leonard H. Augenlicht, Martin Lipkin

Abstract

We reported previously that a new Western-style diet (NWD) for 18 months, consisting of elevated lipids and decreased calcium, vitamin D and methyl-donor nutrients, induced colonic tumors in normal C57Bl/6 mice [Newmark, H.L. et al. (2001) A Western-style diet induces benign and malignant neoplasms in the colon of normal C57Bl/6 mice. Carcinogenesis, 22, 1871-1875], suggesting a new mouse model for human sporadic colon cancer. Here, we have extended this study during a longer feeding period of 2 years wherein tumor formation, tumor inhibition by addition of dietary calcium and vitamin D and their effects on gene expression were determined. We also similarly tested individual supplements of methyl donor (transfer) nutrients (folic acid, choline, methionine and dietary fiber), but these had no significant effect on colonic tumor incidence or multiplicity, whereas supplementation with combined calcium and vitamin D produced significant decrease in both colon tumor incidence and multiplicity, during 2 years of feeding. No visible colonic tumors were found at 6 months, very few at 12 months, more at 18 months and significantly at 24 months. In a related study of gene changes of the mouse colonic mucosa at 6 months of feeding taken from this study, long before any tumors were visibly detectable, indicated altered profiles of gene expression linked to later risk of dietary initiation of colon tumor formation. This type of early genetic altered profile, an indication of increased risk of later colonic tumor development, may become a useful tool for prediction of colon tumor risk while the colon grossly still appears histologically and physiologically normal.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 95 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Hungary 1 1%
United States 1 1%
Unknown 93 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 25 26%
Researcher 15 16%
Student > Master 13 14%
Student > Bachelor 8 8%
Other 6 6%
Other 12 13%
Unknown 16 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 30 32%
Biochemistry, Genetics and Molecular Biology 19 20%
Medicine and Dentistry 15 16%
Immunology and Microbiology 3 3%
Pharmacology, Toxicology and Pharmaceutical Science 2 2%
Other 5 5%
Unknown 21 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 January 2011.
All research outputs
#7,521,897
of 22,955,959 outputs
Outputs from Carcinogenesis
#1,663
of 4,759 outputs
Outputs of similar age
#31,627
of 88,152 outputs
Outputs of similar age from Carcinogenesis
#16
of 40 outputs
Altmetric has tracked 22,955,959 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,759 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.4. This one is in the 22nd percentile – i.e., 22% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 88,152 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 40 others from the same source and published within six weeks on either side of this one. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.