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Seasonality of vitamin D status and bone turnover in patients with Crohn's disease

Overview of attention for article published in Alimentary Pharmacology & Therapeutics, April 2005
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Title
Seasonality of vitamin D status and bone turnover in patients with Crohn's disease
Published in
Alimentary Pharmacology & Therapeutics, April 2005
DOI 10.1111/j.1365-2036.2005.02446.x
Pubmed ID
Authors

D. McCarthy, P. Duggan, M. O'Brien, M. Kiely, J. McCarthy, F. Shanahan, K. D. Cashman

Abstract

While winter-time vitamin D deficiency has been well-documented in Crohn's disease patients, less is known about vitamin D status during summertime and whether a seasonal variation exists in bone turnover. To compare vitamin D status and bone turnover markers in Crohn's disease patients with age- and sex-matched controls during late-summer and late-winter. Crohn's disease patients (n = 44; mean age 36.9 years, currently in remission) and matched controls (n = 44) were recruited from Cork University Hospital and Cork City area, respectively. Bloods were analysed for 25-hydroxyvitamin D, parathyroid hormone, bone-specific alkaline phosphatase, osteocalcin and urine analysed for N-telopeptides of type 1 collagen. Serum 25-hydroxyvitamin D concentrations were significantly (P < 0.003) lower in Crohn's disease patients than in control subjects during both seasons. In Crohn's disease patients, serum 25-hydroxyvitamin D concentrations were lower (P < 0.0001) whereas serum parathyroid hormone, osteocalcin and bone-specific alkaline phosphatase and urinary N-telopeptides of type 1 collagen levels were higher (P < 0.001) during late-winter than late-summer. There were notable seasonal variations in vitamin D status and bone turnover markers in Crohn's disease patients. The impact of winter decline in vitamin D status and increase in bone turnover on long-term risk of osteopenia/osteoporosis in Crohn's disease patients is unclear.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 56 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
Spain 1 2%
Denmark 1 2%
France 1 2%
Unknown 52 93%

Demographic breakdown

Readers by professional status Count As %
Researcher 9 16%
Student > Master 8 14%
Student > Ph. D. Student 7 13%
Other 5 9%
Student > Doctoral Student 4 7%
Other 13 23%
Unknown 10 18%
Readers by discipline Count As %
Medicine and Dentistry 25 45%
Agricultural and Biological Sciences 9 16%
Nursing and Health Professions 2 4%
Biochemistry, Genetics and Molecular Biology 1 2%
Immunology and Microbiology 1 2%
Other 3 5%
Unknown 15 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 January 2011.
All research outputs
#8,534,976
of 25,374,647 outputs
Outputs from Alimentary Pharmacology & Therapeutics
#2,809
of 5,633 outputs
Outputs of similar age
#24,409
of 69,768 outputs
Outputs of similar age from Alimentary Pharmacology & Therapeutics
#17
of 35 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,633 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.9. This one is in the 31st percentile – i.e., 31% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 69,768 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 35 others from the same source and published within six weeks on either side of this one. This one is in the 5th percentile – i.e., 5% of its contemporaries scored the same or lower than it.