| Title |
Thinness at birth and insulin resistance in adult life
|
|---|---|
| Published in |
Diabetologia, February 1994
|
| DOI | 10.1007/s001250050086 |
| Pubmed ID | |
| Authors |
D. I. W. Phillips, D. J. P. Barker, C. N. Hales, S. Hirst, C. Osmond |
| Abstract |
Type 2 (non-insulin-dependent) diabetes mellitus may originate through impaired development in fetal life. Both insulin deficiency and resistance to the action of insulin are thought to be important in its pathogenesis. Although there is evidence that impaired fetal development may result in insulin deficiency, it is not known whether insulin resistance could also be a consequence of reduced early growth. Insulin resistance was therefore measured in 81 normoglycaemic subjects, and 22 subjects with impaired glucose tolerance, who were born in Preston, UK, between 1935 and 1943. Their birth measurements had been recorded in detail. Insulin resistance was measured by the insulin tolerance test which uses the rate of fall in blood glucose concentrations after intravenous injection of insulin as an index of insulin resistance. Men and women who were thin at birth, as measured by a low ponderal index, were more insulin resistant. The association was statistically significant (p = 0.01) and independent of duration of gestation, adult body mass index and waist to hip ratio and of confounding variables including social class at birth or currently. Thinness at birth and in adult life has opposing effects such that resistance fell with increasing ponderal index at birth but rose with increasing adult body mass index. It is concluded that insulin resistance is associated with impaired development in fetal life. |
Mendeley readers
The data shown below were compiled from readership statistics for 112 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| Unknown | 111 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 22 | 20% |
| Student > Ph. D. Student | 17 | 15% |
| Student > Master | 16 | 14% |
| Student > Bachelor | 15 | 13% |
| Professor > Associate Professor | 6 | 5% |
| Other | 16 | 14% |
| Unknown | 20 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 31 | 28% |
| Agricultural and Biological Sciences | 26 | 23% |
| Biochemistry, Genetics and Molecular Biology | 9 | 8% |
| Nursing and Health Professions | 5 | 4% |
| Sports and Recreations | 3 | 3% |
| Other | 14 | 13% |
| Unknown | 24 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 21. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 November 2022.
All research outputs
#1,510,159
of 23,090,520 outputs
Outputs from Diabetologia
#829
of 5,094 outputs
Outputs of similar age
#930
of 71,487 outputs
Outputs of similar age from Diabetologia
#2
of 14 outputs
Altmetric has tracked 23,090,520 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,094 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 22.7. This one has done well, scoring higher than 83% of its peers.
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We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 85% of its contemporaries.