| Title |
Epigenetic Regulation of Pancreatic Islets
|
|---|---|
| Published in |
Current Diabetes Reports, August 2013
|
| DOI | 10.1007/s11892-013-0403-y |
| Pubmed ID | |
| Authors |
Cecile Haumaitre |
| Abstract |
Epigenetic mechanisms, including DNA methylation, histone modifications, and noncoding RNA expression, contribute to regulate islet cell development and function. Indeed, epigenetic mechanisms were recently shown to be involved in the control of endocrine cell fate decision, islet differentiation, β-cell identity, proliferation, and mature function. Epigenetic mechanisms can also contribute to the pathogenesis of complex diseases. Emerging knowledge regarding epigenetic mechanisms suggest that they may be involved in β-cell dysfunction and pathogenesis of diabetes. Epigenetic mechanisms could predispose to the diabetic phenotype such as decline of β-cell proliferation ability and β-cell failure, and account for complications associated with diabetes. Better understanding of epigenetic landscapes of islet differentiation and function may be useful to improve β-cell differentiation protocols and discover novel therapeutic targets for prevention and treatment of diabetes. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 39 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | 3% |
| United States | 1 | 3% |
| Canada | 1 | 3% |
| Unknown | 36 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 9 | 23% |
| Researcher | 8 | 21% |
| Student > Bachelor | 6 | 15% |
| Student > Master | 4 | 10% |
| Other | 2 | 5% |
| Other | 6 | 15% |
| Unknown | 4 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 15 | 38% |
| Agricultural and Biological Sciences | 15 | 38% |
| Medicine and Dentistry | 4 | 10% |
| Nursing and Health Professions | 1 | 3% |
| Unknown | 4 | 10% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 August 2013.
All research outputs
#18,342,133
of 22,715,151 outputs
Outputs from Current Diabetes Reports
#772
of 1,004 outputs
Outputs of similar age
#148,443
of 198,117 outputs
Outputs of similar age from Current Diabetes Reports
#13
of 20 outputs
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We're also able to compare this research output to 20 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.