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Mendeley readers
Attention Score in Context
| Title |
Coupling of Mitochondrial Import and Export Translocases by Receptor-Mediated Supercomplex Formation
|
|---|---|
| Published in |
Cell, August 2013
|
| DOI | 10.1016/j.cell.2013.06.033 |
| Pubmed ID | |
| Authors |
Jian Qiu, Lena-Sophie Wenz, Ralf M. Zerbes, Silke Oeljeklaus, Maria Bohnert, David A. Stroud, Christophe Wirth, Lars Ellenrieder, Nicolas Thornton, Stephan Kutik, Sebastian Wiese, Agnes Schulze-Specking, Nicole Zufall, Agnieszka Chacinska, Bernard Guiard, Carola Hunte, Bettina Warscheid, Martin van der Laan, Nikolaus Pfanner, Nils Wiedemann, Thomas Becker |
| Abstract |
The mitochondrial outer membrane harbors two protein translocases that are essential for cell viability: the translocase of the outer mitochondrial membrane (TOM) and the sorting and assembly machinery (SAM). The precursors of β-barrel proteins use both translocases-TOM for import to the intermembrane space and SAM for export into the outer membrane. It is unknown if the translocases cooperate and where the β-barrel of newly imported proteins is formed. We established a position-specific assay for monitoring β-barrel formation in vivo and in organello and demonstrated that the β-barrel was formed and membrane inserted while the precursor was bound to SAM. β-barrel formation was inhibited by SAM mutants and, unexpectedly, by mutants of the central import receptor, Tom22. We show that the cytosolic domain of Tom22 links TOM and SAM into a supercomplex, facilitating precursor transfer on the intermembrane space side. Our study reveals receptor-mediated coupling of import and export translocases as a means of precursor channeling. |
Mendeley readers
The data shown below were compiled from readership statistics for 193 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 3 | 2% |
| Canada | 2 | 1% |
| Czechia | 1 | <1% |
| Japan | 1 | <1% |
| United States | 1 | <1% |
| Poland | 1 | <1% |
| Unknown | 184 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 41 | 21% |
| Student > Ph. D. Student | 36 | 19% |
| Student > Bachelor | 23 | 12% |
| Student > Master | 23 | 12% |
| Student > Doctoral Student | 12 | 6% |
| Other | 20 | 10% |
| Unknown | 38 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 75 | 39% |
| Biochemistry, Genetics and Molecular Biology | 50 | 26% |
| Medicine and Dentistry | 6 | 3% |
| Chemistry | 6 | 3% |
| Immunology and Microbiology | 5 | 3% |
| Other | 11 | 6% |
| Unknown | 40 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 31. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 December 2014.
All research outputs
#1,294,461
of 25,837,817 outputs
Outputs from Cell
#4,438
of 17,278 outputs
Outputs of similar age
#10,778
of 212,527 outputs
Outputs of similar age from Cell
#61
of 156 outputs
Altmetric has tracked 25,837,817 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 17,278 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 59.7. This one has gotten more attention than average, scoring higher than 74% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 212,527 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 156 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.