| Title |
Pyoderma Gangrenosum: An Update on Pathophysiology, Diagnosis and Treatment
|
|---|---|
| Published in |
American Journal of Clinical Dermatology, February 2017
|
| DOI | 10.1007/s40257-017-0251-7 |
| Pubmed ID | |
| Authors |
Afsaneh Alavi, Lars E. French, Mark D. Davis, Alain Brassard, Robert S. Kirsner |
| Abstract |
Pyoderma gangrenosum (PG) is a rare inflammatory neutrophilic disorder with prototypical clinical presentations. Its pathophysiology is complex and not fully explained. Recent information regarding the genetic basis of PG and the role of auto-inflammation provides a better understanding of the disease and new therapeutic targets. PG equally affects patients of both sexes and of any age. Uncontrolled cutaneous neutrophilic inflammation is the cornerstone in a genetically predisposed individual. Multimodality management is often required to reduce inflammation, optimize wound healing, and treat underlying disease. A gold standard for the management of PG does not exist and high-level evidence is limited. Multiple factors must be taken into account when deciding on the optimum treatment for individual patients: location, number and size of lesion/ulceration(s), extracutaneous involvement, presence of associated disease, cost, and side effects of treatment, as well as patient comorbidities and preferences. Refractory and rapidly progressive cases require early initiation of systemic therapy. Newer targeted therapies represent a promising pathway for the management of PG, and the main focus of this review is the management and evidence supporting the role of new targeted therapies in PG. |
X Demographics
The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| India | 1 | 17% |
| United Kingdom | 1 | 17% |
| Unknown | 4 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 83% |
| Practitioners (doctors, other healthcare professionals) | 1 | 17% |
Mendeley readers
The data shown below were compiled from readership statistics for 193 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 193 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 23 | 12% |
| Researcher | 20 | 10% |
| Student > Doctoral Student | 20 | 10% |
| Student > Postgraduate | 19 | 10% |
| Other | 17 | 9% |
| Other | 34 | 18% |
| Unknown | 60 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 101 | 52% |
| Agricultural and Biological Sciences | 5 | 3% |
| Nursing and Health Professions | 5 | 3% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 2% |
| Biochemistry, Genetics and Molecular Biology | 3 | 2% |
| Other | 13 | 7% |
| Unknown | 62 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 February 2023.
All research outputs
#6,990,568
of 24,805,946 outputs
Outputs from American Journal of Clinical Dermatology
#500
of 1,044 outputs
Outputs of similar age
#105,785
of 316,053 outputs
Outputs of similar age from American Journal of Clinical Dermatology
#14
of 30 outputs
Altmetric has tracked 24,805,946 research outputs across all sources so far. This one has received more attention than most of these and is in the 71st percentile.
So far Altmetric has tracked 1,044 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.1. This one has gotten more attention than average, scoring higher than 52% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 316,053 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.
We're also able to compare this research output to 30 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 56% of its contemporaries.