Title |
Curcumin attenuates surgery-induced cognitive dysfunction in aged mice
|
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Published in |
Metabolic Brain Disease, February 2017
|
DOI | 10.1007/s11011-017-9970-y |
Pubmed ID | |
Authors |
Xiang Wu, Huixin Chen, Chunhui Huang, Xinmei Gu, Jialing Wang, Dilin Xu, Xin Yu, Chu Shuai, Liping Chen, Shun Li, Yiguo Xu, Tao Gao, Mingrui Ye, Wei Su, Haixiong Liu, Jinrong Zhang, Chuang Wang, Junping Chen, Qinwen Wang, Wei Cui |
Abstract |
Post-operative cognitive dysfunction (POCD) is associated with elderly patients undergoing surgery. However, pharmacological treatments for POCD are limited. In this study, we found that curcumin, an active compound derived from Curcuma longa, ameliorated the cognitive dysfunction following abdominal surgery in aged mice. Further, curcumin prevented surgery-induced anti-oxidant enzyme activity. Curcumin also increased brain-derived neurotrophic factor (BDNF)-positive area and expression of pAkt in the brain, suggesting that curcumin activated BDNF signaling in aged mice. Furthermore, curcumin neutralized cholinergic dysfunction involving choline acetyltransferase expression induced by surgery. These results strongly suggested that curcumin prevented cognitive impairments via multiple targets, possibly by increasing the activity of anti-oxidant enzymes, activation of BDNF signaling, and neutralization of cholinergic dysfunction, concurrently. Based on these novel findings, curcumin might be a potential agent in POCD prophylaxis and treatment. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 2 | 50% |
Unknown | 2 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 50% |
Practitioners (doctors, other healthcare professionals) | 1 | 25% |
Scientists | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 45 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 10 | 22% |
Student > Ph. D. Student | 5 | 11% |
Student > Master | 3 | 7% |
Researcher | 3 | 7% |
Student > Doctoral Student | 2 | 4% |
Other | 5 | 11% |
Unknown | 17 | 38% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 10 | 22% |
Neuroscience | 4 | 9% |
Nursing and Health Professions | 3 | 7% |
Agricultural and Biological Sciences | 3 | 7% |
Psychology | 3 | 7% |
Other | 5 | 11% |
Unknown | 17 | 38% |